Bhudev C. Das

professor & J.C. Bose National Fellow

Molecular Oncology
Email: director@acbr.du.ac.in, bcdas48@hostmail.com

Dr. Bhudev C. Das was Founder Director of Institute of Cytology and Preventive Oncology (ICPO) of ICMR, NOIDA before he joined in August 2008, as a senior Professor of Biomedical Sciences and holds the prestigious Prof. Gurbaksh Singh Chair at ACBR. Dr. Das has done his Ph.D from Banaras Hindu University, Varanasi and has worked several years with the Nobel Laureate, Prof. Harald ZurHausen at German Cancer Research Centre (DKFZ), Heidelberg, Germany. He has made outstanding contributions in the field of Cancer Research, Human Genetics and Tumor Virology. During the last 35 years of his distinguished research career he has published more than hundred sixty research papers in reputed international journals and distinguished himself as a renowned molecular oncologist of the country. In India, Dr. Das has pioneered the work on Human Papillomavirus (HPV) that causes cervical and other cancers and his laboratory was the HPV Referral Centre of WHO for whole of South-East Asia. His major areas of interest are biology of HPV, transcriptional regulation of viral oncogenes, development of DNA vaccine and cancer chemotherapeutics and stem cell research. So far 19 Ph.D. and 66 MD/MS/DNB/DM students have received their degrees under his supervision and guidance

Academic Awards/ Honours received

  • Sandoz Oration Award of ICMR for Cancer Research for 1992.

  • American Cancer Society (ACS) International Fellowship Award, 1994 from International Union Against Cancer (UICC), 1995.

  • Fellow of International Union Against Cancer (UICC) since 1996.

  • Elected as a Fellow of National Academy of Sciences (F.N.A.Sc.), Allahabad, in 1998.

  • Received Dr. B.C. Roy National Award and President’s Gold Medal in 1999 by Medical Council of India (MCI), New Delhi.

  • Elected as a Fellow of Indian Academy of Sciences (F.A.Sc.) in 2001.

  • Recognized as a WHO expert for Global HPV Vaccine Program since 2003.

  • Oration Award of Indian Association for Cancer Research, Mumbai in 2004.

  • Elected as a Fellow of National Academy of Medical Sciences (F.A.M.S.), New Delhi in 2004.

  • Elected as a Fellow of Indian National Science Academy (FNA), New Delhi in 2005.

  • Ranbaxy Research Award in Applied Medical Sciences by Ranbaxy Research Foundation for 2005.

  • Elected as President of Indian Association for Cancer Research (IACR), 2006-2009.

  • Pran Nath Chuttani-ICMR Oration Award of National Academy of Medical Sciences (NAMS) for 2006.

  • Ramniklal J. Kinavala Cancer Research Award, of Gujarat Cancer Research Society & Institute, Ahmedabad for 2006.

  • Dr. Prem Nath Wahi Award of ICMR in Preventive Oncology for 2006.

  • J. C. Bose National Fellowship, August 2008 to July 2013.

  • FICCI Award for Innovative R & D in Life Sciences/Applied Research for 2008 – 09.

  • SAASCR Award Society of American Asian Scientists in Cancer Research, 2010.

  • Prof Kameshwar Sahai Bhargava Oration Award of Indian Virological Society in VIRCON 2012, Mukteshwar.

Ongoing Projects:
  1. DST project on “Identification and Characterization of Stem Cells in Pre-cancer and Cancer of the uterine cervix: Contribution of Stem cells in the HPV-associated cervical cancer”. 2008-2013

  2. ICMR project on “Prevalence of high-risk Human Papillomavirus (HR-HPV) Types in Healthy Adolescents and Women with Cervical Carcinoma in Tamilnadu” 2010-2012

  3. DBT project on “Development of Folate Receptor – Mediated system for Targeted Delivery of Curcumin in Cancer Cells”. 2009-2011

Selected Recent Publications:
  1. Sutapa Mahata, Alok C. Bharti, Shirish Shukla, Abhishek Tyagi, Syed A. Husain and Bhudev C. Das Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. MOL. CANCER [In Press] 2011.

  2. Shukla S, Bharti AC, Mahata S, Hussain S, Hedau S, Sharma R, Pillai MR, Krishna S, Chiplunkar S, Tengaonkar H, Das BC. Application of a Multiplex PCR to cervical cells collected by a paper smear for the simultaneous detection of all mucosal human papillomaviruses and typing of HR HPV types 16 and 18. J MED MICROBIOL. 59:1303-10, 2010.

  3. Alok C Bharti, Shirish Shukla, Sutapa Mahata, Suresh Hedau and Bhudev C Das Human Papillomavirus and control of cervical cancer in India; EXPERT REVIEWS IN OBSTET & GYNAECOLOGY. 5,329-346, 2010.

  4. Wilkinson DE, Baylis SA, Padley D, Heath AB, Ferguson M, Pagliusi SR, Quint WG, Wheeler CM; WHO Collaborative Study Group

  5. Establishment of the 1st World Health Organization international standards for human papillomavirus type 16 DNA and type 18 DNA. INTERNATIONAL JOURNAL OF CANCER, 15:126(12):2969-83, 2010.

  6. Mishra Alok, Bharti Alok C, Saluja Daman, Das BC, Trans-activation and expression patterns of Jun and Fos/AP-1 super family proteins in human oral cancer, INTERNATIONAL JOURNAL of CANCER, 126:819- 829, 2009.

  7. Kar P, Jilani N, Husain SA, Pasha ST, Anand R, Rai A, Das BC. Does hepatitis E viral load and genotypes influence the final outcome of acute live failure during pregnancy. AMERICAN J of GASTROENTEROLOGY, 103:2495-501, 2008.

  8. Das BC, Hussain S, Nasare V, Bharadwaj M. Prospects and Prejudices of Human Papillomavirus Vaccines in India. VACCINE, 26(22):2669-79, 2008.

  9. Shailja Pande, Neeraj Jain, Bhupesh K Prusty, Suresh Bhambhani, Sanjay Gupta, Rajyashri Sharma, Swaraj Batra, Bhudev C. Das. HPV-16 variant analysis of E6, E7, L1 Genes and long control region in cervical cancer patients from North India. J CLINICAL MICROBIOLOGY 46:1060-6, 2008.

  10. Prusty BK, Hedau S, Singh A, Kar P, Das BC. Selective Suppression of NF-kBp65 in Hepatitis Virus-Infected Pregnant Women Manifesting Severe Liver Damage and High Mortality. MOL MED. 13:518-26. 2007.

  11. B.C. Das, SK Sarin, Kazim SN, Bharti AC “Infections”: In Cancer Awareness Prevention and Control: Strategies for South Asia. A UICC handbook for South Asia, Geneva, 119-131. 2006.