Faculty


Manisha Yadav

Assistant Professor

Medical Microbiology and Immunology
Email: manisha.dhanda@gmail.com, myadav@acbr.du.ac.in

Dr. Manisha Yadav did her Ph.D. from Post Graduate Institute of Medical Education and Research, Chandigarh, India. During that time she was awarded “Major General Amir Chand Medal for Research” for her PhD work. After her PhD, she initially joined as a Postdoctoral fellow and later as Research Assistant in the Department of Microbiology, Immunology and Glycobiology of Lund University, Sweden. During this time, she worked to investigate the molecular basis of host cell signalling in innate immune responses to uro-pathogenic Escherichia coli and the disease association of the responsible genes.

Areas of Research Interest:

Dr Manisha is working to identify the host receptors and the host-parasite’s pathways involved in the symptomatic and asymptomatic sequelae and immune evasion caused by Trichomoniasis, Sepsis and Urinary Tract Infections (UTI). Since there is an urgent need to understand and prevent the negative impact of this parasite on women’s reproductive health and to prevent the risk of other associated sexually transmitted diseases.

We are also working to identify the host molecules responsible for acute inflammation and particular virulence factors triggering the inflammatory pathway after Uropathogenic E.coli (UPEC) infection. Ultimately identification of target molecules either in the host or in bacteria may prove to be a better approach to win over this disease.

The complexity of the acquisition and spread of Multiple Drug Resistant phenotypes pose a significant threat to human health. As they entail serious therapeutic challenges due to their ability to withstand the effect of different classes of antimicrobial agents. So there is an urgent need to update the antibiotic resistant pattern prevalent worldwide for improving the empirical prescription of general practitioners regarding antibiotics usages during most common community acquired infections like UTI. There is also a need of investigating the mechanism behind antibiotic resistance by devising different strategies in order to better understand such diseases. We are looking out for a possible mechanism or factor(s) behind the antibiotic resistance by investigating antibiotic susceptibility pattern and clonal group pattern in E. coli worldwide, along with our international collaborators. These studies will be helpful to understand the role of antibiotic susceptibility pattern & clonal groups, which can be further exploited as a therapeutic means for the treatment of UTI infection.

Honours & Awards:

  • FAST track for Young Scientist Award from DST, India. 2011

  • Rapid Grant for Young Investigator Award (RGYI) from DBT, India. 2011

  • Maggie Stephens Stiftelse award at Lund University, Sweden. 2010.

  • Bill and Melinda Gates foundation ICOPA bursary award, Scotland, UK. 2006

  • Major General Amir Chand “Medal For Research For The Year 2005”, PGIMER, Chandigarh, India. 2005

Ongoing Projects:

  • TLR and signalling mechanisms of Trichomonas vaginalis isolates from symptomatic and asymptomatic infected women (DBT).

  • Understanding the association between the prevalence of antibiotic resistance and CRISPR repeats in UPEC E. coli causing UTI (Indo-Swedish project).

Selected Recent Publications:
  1. 01.D. Nagarjuna, R. Gaind, RS Dhanda, M. Yadav (2017). Whole Genome Shotgun sequence of Escherichia coli strain MN067 from India: A commensal with a potent pathogenic ability. Genome Announcement, In Press.

  2. 02.V Verma, RS Dhanda, NF Møller, Yadav M (2016). Inflammasomes and their role in innate immunity of Sexually Transmitted Infections. Frontiers in Immunology, 7:540.

  3. 03.Jain S, Nagarjuna D, Gaind R, Chopra S, Dawar R, Sardana R, Yadav M (2016). Escherichia vulneris: An unusual cause of complicated Diarrhoea and Sepsis in an infant. A Case report & Review of Literature. New Microbes and New Infect, 13: 83-86.

  4. 04.V. Verma, D. Nagarjuna, P. Kumar, RS Dhanda, M Yadav (2016). Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells. Data in Brief, 3;7:445-8.

  5. 05.V. Verma, D. Nagarjuna, G, Mittal, P. Kumar, RS Dhanda, R. Gaind, M. Yadav (2016). Data showing phenotypic profile of uropathogenic Escherichia coli isolates from sepsis patients. Data in Brief, 7:794-797

  6. 06.SC Sonkar, S Yadav, N Malla, RS Dhanda, S Khurana, R Bagga, D Saluja, Yadav M (2016). Evaluation of DNA Based Techniques for the Diagnosis of Human Vaginal Trichomoniasis in North Indian Population. British Microbiology Research Journal, 17 (6): 1-12.

  7. 07.Kumar T, Yadav M, Singh LR (2016). Role of osmolytes in regulating immune system. Curr. Pharm. Des., 7. 22: 3050-7.

  8. 08.K. Yadav, D. Yadav, M. Yadav, S. Kumar (2016). Noscapine Loaded PLGA Nanoparticles Prepared Using Oil-in-Water Emulsion Solvent Evaporation Method. Journal of Nanopharmaceutics and Drug Delivery, Vol. 3, 97-105.

  9. 09.D. Nagarjuna, G. Mittal, RS Dhanda, PK Verma, R. Gaind, M. Yadav (2015). Fecal Escherichia coli isolates show potential to cause endogenous infection in patients admitted to ICU in a Tertiary Care hospital. New Microbes and New Infect, 7: 57–66.

  10. 10.D. Nagarjuna, RS Dhanda, R. Gaind, M. Yadav (2015). tcpC as a prospective new virulence marker in blood Escherichia coli isolates from sepsis patients admitted to the intensive care unit. New Microbes and New Infections, 7: 28–30.

  11. 11.K. Yadav, D. Yadav, M. Yadav, S. Kumar (2015). Noscapine-loaded PLA Nanoparticles: Systematic Study of Effect of Formulation and Process Variables on Particle Size, Drug Loading and Entrapment Efficiency. Pharmaceutical Nanotechnology, 3 (2): 137-147.

  12. 12.N. Malla, K. Goyal, RS Dhanda, M. Yadav (2014). Immunity in urogenital protozoa. Parasite immunology, 36 (9), 400­408.

  13. 13.M. Yadav, N. Verma, RS Dhanda (2013). Impact of sexually transmitted infections on women health. Health, 5(8): 1216-26.

  14. 14.Norinder BS, Köves B, M. Yadav, Brauner A, Svanborg C (2012). Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire? Microbial Pathogenesis, 52(1): 10-6.

  15. 15.M. Svensson, M. Yadav, B Holmqvist, N. Lutey, C. Svanborg, G. Godaly (2011). Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice. Kidney International, 80(10): 1064-72.

  16. 16.Norinder BS, P. Luthje, M. Yadav, L. Kadas, H. Fang, CE Nord, A. Brauner (2011). Cellulose and PapG are important for Escherichia coli causing recurrent urinary tract infection in women. Infection, 39(6): 571-4.

  17. 17.Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, Lum J, Miethke T, Svanborg C (2010). Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence. PLoS Pathogen, Sep 23; 6(9).

  18. 18.Fischer H, Lutay N, Ragnarsdóttir B, Yadav M, Jönsson K, Urbano A, Al Hadad A, Rämisch S, Storm P, Dobrindt U, Salvador E, Karpman D, Jodal U, Svanborg C (2010). Pathogen-specific, IRF3-dependent signaling and innate resistance to human kidney infections. PLoS Pathogen, Sep 23; 6(9).

  19. 19.A. Egesten, AI Olin, HM Linge, M. Yadav, M. Möregelin, A. Karlsson, M Collin (2009). SpeB of Streptococcus pyogenes differentially modulates antibacterial and receptor activating properties of human chemokines. PLoS ONE, 4 (3): 1-9.

  20. 20.C. Cirl, A. Wieser, M. Yadav, S. Duerr, S. Schubert, H. Fischer, D. Stappert, N. Wantia, N. Rodriguez, H. Wagner, C. Svanborg, T. Miethke (2008). Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins. Nature Medicine, 14(4): 399-406.