Manisha Yadav


Medical Microbiology and Immunology
Email: manisha.dhanda@gmail.com, myadav@acbr.du.ac.in

Prof. Manisha Yadav did her Ph.D. (2006) from Post Graduate Institute of Medical Education and Research, Chandigarh, India. During that time she was awarded "Major General Amir Chand Medal for Research" for her PhD work. After her PhD, she joined as a Postdoctoral fellow (2006-2010) in the Department of Microbiology, Immunology and Glycobiology of Lund University, Sweden. Prof. Yadav has received several national and international awards and fellowships. She is also involved in the administrative duties of the Delhi University.

Prof. Yadav is working to identify the host receptors and the host-parasite's pathways involved in the symptomatic and asymptomatic sequelae and immune evasion caused by Trichomoniasis, Sepsis and Urinary Tract Infections (UTI). We are also working to identify the host molecules responsible for acute inflammation and particular virulence factors triggering the inflammatory pathway after Uropathogenic E.coli (UPEC) infection. Ultimately identification of target molecules either in the host or in bacteria may prove to be a better approach to win over this disease.

The complexity of the acquisition and spread of Multiple Drug Resistant phenotypes pose a significant threat to human health. As they entail serious therapeutic challenges due to their ability to withstand the effect of different classes of antimicrobial agents. We are looking out for a possible mechanism or factor(s) behind the antibiotic resistance by investigating antibiotic susceptibility pattern and clonal group pattern in E. coli worldwide, along with our international collaborators. Working to understand the association between the prevalence of antibiotic resistance and CRISPR repeats in UPEC causing UTIs. Also working for the design/development of target specific antibiofilm compounds in UTI patients. These studies will be helpful to understand the possible mechanism or factor(s) behind the antibiotic resistance, which can be further exploited as a therapeutic means for the treatment of UTI infection.

Looking for Telented Ph.D. Students. Please contact via email: manisha.dhanda@gmail.com

Honours & Awards:

  1. 1. ICMR-DHR international Fellowship from Department of Health Research, Ministry of Health and Family Welfare, India. 2018.

  2. 2. FAST track for Young Scientist Award from DST, India. 2011

  3. 3. Rapid Grant for Young Investigator Award (RGYI) from DBT, India. 2011

  4. 4. Maggie Stephens Stiftelse award at Lund University, Sweden. 2010.

  5. 5. Bill and Melinda Gates foundation ICOPA bursary award, Scotland, UK. 2006

Ongoing Projects:

  1. 1. TLR and signalling mechanisms of Trichomonas vaginalis isolates from symptomatic and asymptomatic infected women (DBT).

  2. 2. Understanding the association between the prevalence of antibiotic resistance and CRISPR repeats in UPEC E. coli causing UTI (Indo-Swedish project).

Selected Recent Publications:
  1. 1. Yadav Manisha and Malla N. Editorial: Immune Responses in Sexually Transmitted Infections Caused by Parasites and DNA Viruses: New Insights. Front. Cell. Infect. Microbiol. Jan 2022, 12:838799. doi: 10.3389/fcimb.2022.838799.

  2. 2. S Gupta, P Kumar, B Rathi, V Verma, RS Dhanda, P Devi, M Yadav. Targeting of Uropathogenic Escherichia coli papG gene Using CRISPR-dot Nanocomplex reduced Virulence of UPEC. Scientific Reports 2021 Sep 7;11(1):17801. doi: 10.1038/s41598-021-97224-4.

  3. 3. P Kumar, V Verma, D Mohania, S Gupta, A K. Babbar, B Rathi, RS Dhanda, M Yadav. Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells. Journal of Cellular Biochemistry, 2021. DOI: 10.1002/jcb.30126.2021.

  4. 4. A Åkerud, J Axelsson, M Yadav, J Erjefält, G Ekman-Ordeberg, A Malmström, H Fischer. Heparin fragments induce cervical inflammation by recruiting immune cells through Toll-like receptor 4 in nonpregnant mice. Mol Hum Reprod. 2021 Feb 27;27(3): gaab004. doi: 10.1093/molehr/gaab004.

  5. 5. S Yadav, V Verma, RS Dhanda, S Khurana, M Yadav. Latent Upregulation of Nlrp3, Nlrc4 and Aim2 Differentiates between Asymptomatic and Symptomatic Trichomonas vaginalis Infection. Immunol Invest. 2021 Apr 19;1-22. doi: 10.1080/08820139.2021.1909062.

  6. 6. S Shukla, J Telraja, M Yadav, H Prakash. Editorial: Modulation of Macrophage Signaling Pathways during Bacterial Infections. Front. Cellular & Infect. Microb. 2021. doi: 10.3389/fcimb.2021.689759.

  7. 7. V Verma, P Kumar, S Gupta, S Yadav, RS Dhanda, H Thorlacius, M Yadav. Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages. Scientific Reports. 2020 Jul 28;10(1):12653. doi: 10.1038/s41598-020-69501-1.

  8. 8. Yadav S, Verma V, Singh Dhanda R, Yadav M. Insights into the toll-like receptors in sexually transmitted infections. Scand J Immunol. 2020 Aug 6:e12954. doi: 10.1111/sji.12954.

  9. 9. Verma V, Gupta S, Kumar P, Yadav S, Dhanda RS, Gaind R, Arora R, Frimodt-Møller N, Yadav M. Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections. Frontiers in Microbiology. Sep 2019. doi: 10.3389/fmicb.2019.02020.

  10. 10. V Verma, S Gupta, P Kumar, A Rawat, RS Dhanda, M Yadav. Efficient production of endotoxin depleted bioactive ?-hemolysin of Uropathogenic Escherichia coli. Preparative Biochemistry & Biotechnology, March 2019. doi.org/10.1080/10826068.2019.1591993.

  11. 11. Bano N, Yadav M, Das BC. Differential Inhibitory Effects of Curcumin Between HPV+ve and HPV-ve Oral Cancer Stem Cells. Frontiers in Oncology 2018; 8:412.

  12. 12. D. Nagarjuna, G Mittal, RS Dhanda, R Gaind, M Yadav. Alarming levels of antimicrobial resistance among sepsis patients admitted to ICU in a tertiary care hospital in India - a case control retrospective study. Antimicrobial Resistance and Infection Control 2018; 7:150.

  13. 13. D. Nagarjuna, R. Gaind, RS Dhanda, M. Yadav. Whole Genome Shotgun sequence of Escherichia coli strain MN067 from India: A commensal with a potent pathogenic ability. Genome Announcement, 2017 23;5(12).

  14. 14. V Verma, RS Dhanda, NF Møller, Yadav M. Inflammasomes and their role in innate immunity of Sexually Transmitted Infections. Frontiers in Immunology, 2016, 7:540.

  15. 15. Jain S, Nagarjuna D, Gaind R, Chopra S, Dawar R, Sardana R, Yadav M. Escherichia vulneris: An unusual cause of complicated Diarrhoea and Sepsis in an infant. A Case report & Review of Literature. New Microbes and New Infect, 2016, 13: 83-86.

  16. 16. K. Yadav, D. Yadav, M. Yadav, S. Kumar. Noscapine Loaded PLGA Nanoparticles Prepared Using Oil-in-Water Emulsion Solvent Evaporation Method. Journal of Nanopharmaceutics and Drug Delivery, 2016 Vol. 3, 97-105.

  17. 17. D. Nagarjuna, G. Mittal, RS Dhanda, PK Verma, R. Gaind, M. Yadav. Fecal Escherichia coli isolates show potential to cause endogenous infection in patients admitted to ICU in a Tertiary Care hospital. New Microbes and New Infect, 2015 7: 57-66.

  18. 18. D. Nagarjuna, RS Dhanda, R. Gaind, M. Yadav. tcpC as a prospective new virulence marker in blood Escherichia coli isolates from sepsis patients admitted to the intensive care unit. New Microbes and New Infections, 2015 7: 28-30.