Ajay K. YadavAssistant Professor & Prof. Ramalingaswami Fellow
Cancer Genetics Lab
Dr. Ajay K. Yadav started his research career from Industrial toxicology Research center, Lucknow & National Institute of Immunology, New Delhi and PhD from Jamia Hamdard University, New Delhi in the field of Tumor Necrosis Factor- alpha biology. After finishing PhD, Dr. Ajay Kumar moved to Northwestern University, IL(USA), worked for 3-years with Dr. Goberdhan Dimri's laboratory where he studied the deregulated expression of Polycomb proteins at the stage of breast cancer metastasis. Latter he joined Prof. Markus Bredel laboratory where he involved in Glioma genome wide mapping identified novel genetic signatures present in a subsets of Glioblastoma tumor tissues required for disease malignancy.
Current research area is identification and characterization of novel alternative spliced variant. Alternative spliced variant genes are usually of different genetic sequences and conformation formed at the state of pre-mRNA splicing. Skipping of relevant exons leads to formation of alternative proteins with gain or loss of functions required for stability/de-stability of gene or translated protein. So, tumor suppressor with loss of exons usually go with loss of function are usually formed at accelerated rate during cancer disease progression along with loss of exons in oncogenes seems to deprived of translated protein with domain required for degradation signal, inferred with loss or gain in original gene function. Goal to study the involvement of genetic spliced variant with their relative alternative pathway expression at different diseased state.Honours & Awards:
Prof. Ramalingaswami Fellow (2010-2015)
American society for cell biology Travel Award for attending conference -2009Selected Recent Publications:
- 1. Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, Yu IL, Carro MS, Dai F, Tagge MJ, Ferrarese R, Bredel C, Phillips HS, Lukac PJ, Robe PA, Weyerbrock A, Vogel H, Dubner S, Mobley B, He X, Scheck AC, Sikic BI, Aldape KD, Chakravarti A, Harsh GR 4th. New Engl J Med. 2011 Feb 17;364(7):627-37. Epub 2010 Dec 22.
- 2. Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger and Goberdhan P Dimri. Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain. Mol. Cancer 2010 Jun 22;9:158
- 3. Ajay K. Yadav, Jaclyn J. Renfrow, Denise M. Scholtens, Hehuang Xie, George E. Duran, Claudia Bredel, Hannes Vogel, James P. Chandler, Arnab Chakravarti, Pierre A. Robe, Sunit Das, Adrienne C. Scheck, John A. Kessler, Marcelo B. Soares, Branimir I. Sikic, Griffith R. Harsh, and Markus Bredel. Monosomy of Chromosome 10 Associated With Dysregulation of Epidermal Growth Factor Signaling in Glioblastomas Journal of Am. Med. Association. 2009;302(3):276-289.
Was Highlighted in Nature Vol (460) 23rd July 2009, pp438, Cancer Biology section and was under wide media coverage.
- 4. Markus Bredel, Denise M. Scholtens, Griffith R. Harsh, Claudia Bredel, James P. Chandler, Jaclyn J. Renfrow, Ajay K. Yadav, Hannes Vogel, Adrienne C. Scheck, Robert Tibshirani, Branimir I. Sikic. A Network Model of a Cooperative Genetic Landscape in Brain Tumors. Journal of Am. Med. Association, 2009;302(3):261-275.
- 5. Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res., Jun 1;67(11):5083-9,2007.
- 6. Yadav A, Kalita A, Dhillon S, Banerjee K. JAK/STAT3 pathway is involved in survival of neurons in response to insulin like growth factor and negatively regulated by suppression of cytokine signaling-3. J. Biol. Chem., Vol. 280,36(9), pp- 31830-31840, 2005.
- 7. Kenchappa P, Yadav A, Singh G, Nandana S, Banerjee K. Rescue of TNF -inhibited neuronal cells by IGF-1 involves Akt and c-Jun N-terminal kinases. J. Neurosci. Res., Volume 76, Issue 4, p 466-474,15 May, 2004.
- 8. Yadav AK, Paul BN, Naik S, Saxena AK, Patel DK. Human Hemaglobin shares the Bioactivities ascribed to Human Tumor Necrosis Factor- alpha. Immunopharmacol. & Immonotoxicol., Vol-26, No-4, PP:1-14, 2004
- 9. Paul BN, Prakash A, Kumar S, Yadav AK, Mani U, Saxena AK, Sahu AP, Lal K, Dutta KK. Silica induced early fibrogenic reaction in lung of mice ameliorated by Nyctanthes arbortristis extract. Biomed. Environ. Sci., Sep.; 15(3); 215-22, 2002.