Anju Katyal


Molecular Immunology & Microbiology
Email: anju_katyal@yahoo.com

Dr. Anju Katyal did her Ph. D from Deptt. of Parasitology, PGIME&R, Chandigarh . Her research work pertained to the possible implications of the use of calcium channel blockers in treating drug resistant malarias and found out that CCB can be detrimental for causing severe malaria conditions.

She joined ACBR as faculty in 1998, where in She continued work on malarial immunology and immunopathogenesis. Presently, her group is exploring the modulatory role of various cytokines, proinflammatory molecules, oxidative stress and apoptosis in immuno-pathological conditions during cerebral malaria, cerebral ischemia and cerebral hypoxia. The long term objectives are to explore the critical role of these pathways and individual molecules in the pathogenesis of these clinical conditions.

Her group also works on animal model for alcoholic liver disease to characterize the antigens involved in pathogenesis and longitudinal progression of disease. Present work is aimed at isolating and characterizing the specific antigen which elicits auto-immune response and their relative contribution in progression of disease is being investigated.

Ongoing Projects:
  1. “Investigation of regulatory role of cholinergic system on apoptosis and inflammation in murine model of global cerebral ischemia., ICMR, 2009-2012.

  2. ”Evaluation of the protective role of Hypericum perforatum in chronic hypobaric hypoxia induced neuronal degeneration and memory dysfunction ”, ICMR, 2009-2012

  3. ”Investigation of the role of Zinc in hypobaric hypoxia induced memory impairment and neuronal damage”, UGC, 2009-2012.

Selected Recent Publications:
  1. 25. Choudhary R, Kumar M, Katyal A. (2022).12/15-Lipoxygenase debilitates mitochondrial health in intermittent hypobaric hypoxia induced neuronal damage: An in vivo study. Redox biology. 49: 102228

  2. 24. Pasrija P, Girdhar M, Kumar M, Arora S, Katyal A. Endophytes: an unexplored treasure to combat Multidrug resistance (2022). Phytomedicine Plus. 2: 100249

  3. 23. Kumar M, Madan J, Sodhi RK, Singh SB, Katyal A. (2021) Decoding the silent walk of COVID-19: Halting its spread using old bullets. Biomed Pharmacother. 133: 110891

  4. 22. Kiran Jyoti, Sanyog Jain, Om Prakash Katare, Anju Katyal, Ramesh Chandra, Jitender Madan. Non-small cell lung cancer tumour antigen, MUC-1 peptide-loaded non-aggregated poly (lactide-co-glycolide) nanoparticles augmented cellular uptake in mouse professional antigen-presenting cells: optimisation and characterisation. J Microencapsul. 2020 Jan;37(1):14-28

  5. 21. Vandana, Rajnikant Dixit1, Rajnarayan Tiwari, Anju Katya and Kailash C. Pandey. Metacaspases: Potential Drug Target Against Protozoan Parasites Front Pharmacol. 2019;10:790

  6. 20. Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2). Vandana, Singh AP, Singh J, Sharma R, Akhter M, Mishra PK, Saxena AK, Dixit R, Rathi B, Katyal A, Pandey KC Mol Biochem Parasitol. 2018 Mar;220:28-41.

  7. 19. Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress. Choudhary R, Malairaman U, Katyal A. Neuroscience. 2017 Sep 17;359:308-324.

  8. 18. Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells Madan J1, Pandey RS, Jain UK, Katare OP, Aneja R, Katyal A. Colloids Surf B Biointerfaces. 1;107:235-44. 2017

  9. 17. Myeloperoxidase: Bridging the gap in neurodegeneration R.S. Ray, Anju Katyal. Neuroscience and Biobehavioral Reviews 68 (2016) 611–620

  10. 16. Protamine coated proliposomes of recombinant human insulin encased in Eudragit S100 coated capsule offered improved peptide delivery and permeation across Caco-2 cells. Sharma S1, Jyoti K1, Sinha R2, Katyal A2, Jain UK1, Madan J3. Mater Sci Eng C Mater Biol Appl. 2016 ,1;67:378-85.

  11. 15. Tetanus toxoid-loaded cationic non-aggregated nanostructured lipid particles triggered strong humoral and cellular immune responses Kaur A, Jyoti K, Rai S, Sidhu R, Pandey RS, Jain UK, Katyal A, Madan J. J.Microencapsul. 2016 May;33(3):263-73.

  12. 14. Chemical sympathectomy restores baroreceptor-heart rate reflex and heart rate variability in rats with chronic nitric oxide deficiency Chaswal M, Das S, Prasad J, Katyal A, Physiol Res. 2015;64(4):459-66

  13. 16. Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis Kaur K, Sodhi RK, Katyal A, Aneja R, Jain UK, Katare OP, Madan J Colloids Surf B Biointerfaces. 2015 Aug 1;132:225-35

  14. 12. Improved cisplatin delivery in cervical cancer cells by utilizing folate-grafted non-aggregated gelatin nanoparticles Dixit N, Vaibhav K, Pandey RS, Jain UK, Katare OP, Katyal A, Madan J. Biomed Pharmacother. 2015 Feb;69:1-10

  15. 11. Effect of Ca2EDTA on Zinc mediated inflammation and neuronal apoptosis in Hippocampus of an in vivo mouse model of hypobaric hypoxia Udayabanu Malairaman,, Kumaran Dandapani, Anju Katyal PlosOne 2014 ,9(10) ,e 110253

  16. 10. Cholinergic receptor blockade by scopolamine and mecamylamine exacerbates global cerebral ischemia induced memory dysfunction in C57BL/6J mice R.S. Ray, S. Rai, A. Katyal Nitric Oxide 2014, 43 ,62-73

  17. 9. Quercetin mitigates lead acetate induced behavioural and histological alterations 2014via suppression of oxidative stress, Hsp 70, Bak and upregulation of Bcl-2. Krishan Chander et al., Anju Katyal, Fakhrul Islam, M Saeed Siddiqui. Food Chem Toxicol. 2014 .68,297-306

  18. 8. Enhanced noscapine delivery using estrogen-receptor targeted nanoparticles for breast cancer therapy. Anticancer Drugs. Jitender Madan et al. Anju Katyal , Upendra Kumar Jain Anticancer Drugs.2014 ,25(6),704-716.

  19. 7. Sustained-release protamine sulphate-impregnated microspheres may reduce the frequent administration of recombinant interferon a-2b in ovarian cancer: in-vitro characterization Gulia M, Rai S, Jain UK, Katare OP, Katyal A, Madan J. Anticancer Drugs. 2014 Jan;25(1):63-71

  20. 6. Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells. Madan J, Pandey RS, Jain UK, Katare OP, Aneja R, Katyal A. Colloids Surf B Biointerfaces. 2013 Jul 1;107:235-44

  21. 5. Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells Madan J, Pandey RS, Jain V, Katare OP, Chandra R, Katyal A. Nanomedicine. 2013 May;9(4):492-503

  22. 4. Immunoproteomic identification of biotransformed self-proteins from the livers of female Balb/c mice following chronic ethanol administration.Proteomics Kaur I, Katyal A. Proteomics. 2012 Jun;12(12):2036-44

  23. 3. Galactosylated gelatin nanovectors of doxorubicin inhibit cell proliferation and induce apoptosis in hepatocarcinoma cells Garg M, Madan J, Pandey RS, Sardana S, Katyal A, Chandra R. Anticancer Drugs. 2012 Sep;23(8):836-45

  24. 2. Free chelatable zinc modulates the cholinergic function during hypobaric hypoxia-induced neuronal damage: An in vivo study Neuroscience Udayabanu, M., Kumaran, D., Katyal, A Neuroscience 2012 , 202 , pp. 434-445

  25. 1. Effect of Losartan, an angiotensin II type J receptor anatagonist on cardiac autonomic function of rats during acute and chronic inhibition of Nitric oxide synthesis. Chaswal, M., Das, S., Prasad, J., Katyal A., Kumar A, ,Fahim Physiological Reasearch 2012 ,61,135-144.