Dr. Kamna Srivastava

Assistant Professor

Molecular Cardiology Lab
Email: kamstav@yahoo.com Kamna_srivastava@hotmail.com

Dr Kamna Srivastava did her B. Pharm, M. Pharm and PhD from Department of Pharmacology, Institute of Technology from Bananas Hindu University. She has past experience by working at National Institute of Immunology, New Delhi as a Pool-Officer under a CSIR guided project after which she joined All India Institute of Medical Sciences, New Delhi as a postdoctoral fellow.

Areas of Research Interest

Molecular cardiology, Pharmacogenomics, Toxicology and Pharmacology

Cardiovascular diseases (CVD) are one of the major causes of mortality worldwide. Based on their antioxidant and inflammatory potential, candidate genes associated with cardiovascular diseases including various isoforms of Heat Shock Proteins, microRNAs, PCSK9 and various novel biomolecules, our lab is working on developing these molecules in to non-invasive and more effective circulating prognostic biomarkers as compared to the already existing markers used in CVD prognosis and diagnosis. Our laboratory has studied extensively the role of gene and proteins encoding Renin Angiotensin Aldosterone system on blood pressure control with ACE inhibitors in north Indian subjects with essential hypertension.

Presently, lab focuses on studying the regulatory function and signaling crosstalk mediated by small non coding RNAs (sncRNAs) such as miRNAs in coronary artery disease (CAD) and to develop these non-coding RNAs as therapeutic targets as well as potential biomarkers in cardiovascular diseases. In another objective, our laboratory has been studying the role of Heat Shock Proteins gene polymorphisms, expression in whole blood and their correlation with plasma inflammatory markers in North Indian subjects with cardiovascular disorders. In a recent effort to develop biomarker based on lipid parameters, our lab is looking into the pathophysiological mechanism of PCSK9 inhibitors in patients with CAD.

Ongoing Projects:

  1. 1. To study the genetic polymorphism of PCSK9 and their expression at molecular levels in patients with coronary artery disease. (DST-2017-2020)

Selected Recent Publications:

  1. 1. Srivastava K*, Chandra S, Narang R, Bhatia J, Saluja D. E-selectin gene in essential hypertension: a case-control study. Eur J Clin Invest. 2018;48:e12868. https://doi.org/10.1111/eci.12868.

  2. 2. Srivastava K*, Tyagi K. Single nucleotide polymorphisms of microRNA in cardiovascular diseases. ClinicaChimicaActa. 2017 Dec 24.

  3. 3. Kamna Srivastava,*, Swati Chauhan, Sudhir Chandra, Rajiv Narang, Jagriti Bhatia, Daman Saluja. (2016) Haplotype Analysis of Heat Shock Protein70 Gene and Their Association with Essential Hypertension. Ann Clin Exp Hypertension 4(2): 1041.

  4. 4. Kamna Srivastava,*, Rajiv Narang, Jagriti Bhatia, Daman Saluja (2016) Expression of Heat shock protein 70 gene and its correlation with inflammatory markers in essential hypertension PL0s ONE.

  5. 5. Shukla J, Dinda AK, Srivastava AK, Srivastava K, Mittal BR, Bandopadhyaya GP. Nanotamoxifen delivery system: Toxicity assessment after oral administration and biodistribution study after intravenous delivery of radiolabeled nanotamoxifen. World journal of nuclear medicine. 2016 Jan;15(1):7.

  6. 6. Sudhir Chandra, Daman Saluja, Rajiv Narang, Jagriti Bhatia, *Kamna Srivastava (2015). Atrial Natriuretic Peptide and Aldosterone Synthase gene in essential hypertension: a case-control study. Gene; 2015 Apr 24. pii: S0378-1119(15)00489-8. doi: 10.1016/j.gene.2015.04.062.).

  7. 7. Kalyan Srivastava, Kamna Srivastava (2015). Role of Platelet-Mediated Cytoadherence and Chemokines Release in Severe Malaria. SOJ Immunol 3(3): 1-6.

  8. 8. Sudhir Chandra, Rajiv Narang, Sreenivas V, Jagriti Bhatia, Daman Saluja, *Kamna Srivastava (2014) Association of Angiotensin II Type 1 Receptor (A1166C) Gene Polymorphism and Its Increased Expression in Essential Hypertension: A Case-Control Study. PLoS ONE 9(7): e101502.

  9. 9. Sudhir Chandra, Rajiv Narang, Daman Saluja, Jagriti Bhatia, *Kamna Srivastava (2014) Expression of angiotensin-converting enzyme gene in whole blood in patients with essential hypertension. Biomarkers;19(4):314-8.

  10. 10. *Kamna Srivastava, Rajeev Narang, V Sreenivas, Nibhriti Das (2014) Endothelial nitric oxide synthase genes (Intron 4a/b and T786C) polymorphisms in coronary artery disease in north Indian subjects. International journal of current Pharmaceutical and clinical research.

  11. 11. *Kamna Srivastava, Rajeev Narang, V.Sreenivas, Sabari Das, Nibhriti Das (2014) Association of oxidative stress with essential hypertension in Asian Indians. International journal of current Pharmaceutical and clinical research.

  12. 12. *Kamna Srivastava, Sudhir Chandra, Jagriti Bhatia, Rajiv Narang, Daman Saluja (2012) Association of Angiotensinogen (M235T) gene polymorphism with Blood pressure lowering response to Angiotensin Converting Enzyme inhibitor (Enalapril). Journal of Pharmacy and Pharmaceutical Sciences, Vol.15(3)399-406.

  13. 13. *Kamna Srivastava, Indhumathi Narayanan, Sudhir Chandra, Rajiv Narang, Jagriti Bhatia, Daman Saluja (2012) Role of E-Selectin (Ser128Arg) gene polymorphism in patients with essential hypertension in Asian Indians. Journal of Pharmacy Research, vol.5(2)880-882.

  14. 14. N Siddiqui, W Ahsan, K Srivastava (2012). Design, synthesis and anticonvulsant evaluation of pyridinyl-pyrrolidones: A pharmacophore hybrid approach. Arch. Pharm. Chem. Life Sci, Vol. 345(3):185-94.

  15. 15. *Kamna Srivastava, Rajiv Narang, Jagriti Bhatia, Daman Saluja (2012) ?Association of angiotensin converting enzyme ACE (I/D) gene polymorphism with essential hypertension in northern Indian subjects". Genetic Testing and Molecular Biomarkers, Vol.16(3)174-177.