Madhu Chopra

Assistant Professor

Molecular Modelling and Anticancer Drug Development
Email: mchopradu@gmail.commchopra@acbr.du.ac.in

Areas of Research

  1. 1. Drug Development and mechanism
  2. 2. Molecular Modeling, Drug Design and Bioinformatics
  3. 3. Nanotechnology: Nanomaterials and application in drug delivery
  4. We are doing active research in Computer Assisted Drug Design and Development. Using various computational methods such as pharmacophore modelling, 3D QSAR, virtual screening etc. we have identified several lead compounds against important cancer targets. Along with computational design my group is working towards development of anticancer compounds considering GPCR, HDAC and COX-2 as molecular Targets. The projects involve detailed mechanistic studies, protein-protein interaction networks (PPIs) of cancer targets in order to find effective combination therapy regimes against various cancer types.

    In addition, we are also pursuing synthesis of medicinally important compounds. Our group is also involved in isolating natural compounds having anticancer properties using cell based in vitro and in vivo screening methods. Nanoparticle based drug delivery agents is another area which our group is working to give target specific pharmaceutical agents

    Our future plans include....

    • To continue with research projects involving modelling of GPCR, HDAC, cMET: Pharmacophore modelling, 3D QSAR, docking and virtual screening for development novel lead molecules.

    • Virtual screening of plant derived molecules, building databases for virtual screening for drug like compounds.

    • Development of nanoparticle based drug delivery agents

    • Initiate collaborative programmes with other institutions for enriching biodiversity information resources and promoting human resource development in drug discovery and bioinformatics.

    Ongoing Projects:

    1. 1.Creation of Bioinformatics Infrastructure Facility (BIF) at ACBR, DBT, 2012-2017
    1. 2."Design and development of novel inhibitors of AKR1C1 as potential late candidates in treatment of breast, cervical and endometrial cancers"; Sanctioned by MOHFW 2016-19
    1. 3.“Development of Anticancer Therapeutics: Targeting drug loaded nanocarriers to CD44, A Hyaluroan Receptor” Sanctioned by University of Delhi, 2009.
    1. 4.Structure Based Design, Synthesis and Evaluation of Histone Deacetylase Inhibitors as Potent Antitumour Agents, Sanctioned by DBT, 2008.
    1. 5.Biodegradable Nanogels as Potential Drug Delivery Carriers for Development of Target Specific Chemotherapeutic from UGC, 2008.
    1. 6.Isolation, Chemical Characterization and Biological evauation of Potential Anticancer Agents From Boerhavia diffusa Project Proposal sanctioned by ICMR, 2007.
    Selected Recent Publications:
    1. 1. Sinha, R., Singh, P., Saini, N. K., Kumar, A., Pathak, R., Chandolia, A., … Bose, M. (2018). Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival. Tuberculosis, 109. https://doi.org/10.1016/j.tube.2018.01.004

    2. 2. Wasim, L., & Chopra, M. (2017). Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells. Cellular Oncology. https://doi.org/10.1007/s13402-017-0366-0

    3. 3. Identification of Potent Cholecystokinin-B Receptor Antagonists: Synthesis, Molecular Modeling and anti-cancer activity against Pancreatic Cancer Cells., Saroj Kumari, Joyita Chowdhury, Manisha Sikka, Priyanka Verma, Prakash Jha, Anil K. Mishra, Daman Saluja and Madhu Chopra* Med. Chem. Commun., 2017, Accepted Manuscript (DOI: 10.1039/C7MD00171A)

    4. 4. Parveen Kumar, Nalini Yadav, Aruna Chhikara, Madhu Chopra Combinatorial Solid Phase Synthesis: Techniques, Characterization and its Application in Drug Development, Current Biochemical Engineering, 2017, Vol 4 (1), 9-33. 10.2174/2212711903666160622085741.

    5. 5. Strong Anti-tumorous Potential of Nardostachys jatamansi Rhizome Extract on Glioblastoma and In Silico Analysis of its Molecular Drug Targets, Himanshi Kapoor, Nalini Yadav, Madhu Chopra, Sushil Chandra Mahapatra, Veena Agrawal, Curr Cancer Drug Targets. 2017, 17(1) , 74-88.

    6. 6. Kumar, P., Wasim, L., Chopra, M., & Chhikara, A. (2017). Co-delivery of Vorinostat and Etoposide Via Disulfide Cross-Linked Biodegradable Polymeric Nanogels: Synthesis, Characterization, Biodegradation, and Anticancer Activity. AAPS PharmSciTech. https://doi.org/10.1208/s12249-017-0863-5

    7. 7. Panobinostat induces apoptosis via production of reactive oxygen species and synergizes with topoisomerase inhibitors in cervical cancer cells, Lubna Wasim, Madhu Chopra*, Biomedicine and Pharmacotherapy, 2016, 84, 1393–1405 (DOI: 10.1016/j.biopha.2016.10.057)

    8. 8. Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for Osteoarthritis therapy, Priyanka Verma, Krishna Dalal, Madhu Chopra*, Journal of Molecular Modeling, 2016, 22, 178, DOI:10.1007/s00894-016-3035-8.

    9. 9. Parveen Kumar, Gautam Behl, Manisha Sikka, Aruna Chhikara*, Madhu Chopra*, Poly(ethylene glycol)-co-methacrylamide-co-acrylic acid based nanogels for delivery of doxorubicin, Journal of Biomaterials, Polymer Edition, 2016, DOI: 10.1080/09205063. 2016.1207588, published 7th July online.

    10. 10. Behl, G., Sikka, M., Chhikara, A., Chopra, M.(2014). PEG-coumarin based biocompatible self-assembled fluorescent nanoaggregates synthesized via click reactions and studies of aggregation behavior.Journal of Colloid and Interface Science, 416, 151 - 160.

    11. 11. Sharma, G., Kapoor,H., Chopra, M., Kumar, K., Agrawal,V. (2014).Strong larvicidal potential of Artemisia annua leaf extract against malaria (Anopheles stephensi Liston) and dengue (Aedes aegypti L.) vectors and bioassay-driven isolation of the marker compounds. Parasitology Research, 113, 197 – 209.

    12. 12. Ponnan, P., Gupta, S., Chopra, M., Tandon, R., Baghel, A.S., Gupta, G., Prasad, A.K., Rastogi, R.C. Bose, M., Raj, H.G. (2013). 2D-QSAR, Docking Studies, and In Silico ADMET Prediction of Polyphenolic Acetates as Substrates for Protein Acetyltransferase Function of Glutamine Synthetase of Mycobacterium tuberculosis.ISRN Structural BiologyVolume, Article ID 373516, 12 pages,http://dx.doi.org/10.1155/2013/373516.

    13. 13. Behl, G., Sharma, M., Sikka, M., Dahiya, S., Chhikara, A., Chopra, M. (2012). Gallic acid loaded disulfide cross-linked biocompatible polymeric nanogels as controlled release system: synthesis, characterization, and antioxidant activity. Journal of Biomaterials Science, Polymer Edition, 24, 865-881.

    14. 14. Kumari, S., Chaudhury, J., Chandana, S., Saluja, D., Mishra, A.K., Chopra, M. (2012). Synthesis and evaluation of a fluorescent non-peptidic Cholecystokinin-B/Gastrin receptor specific antagonist for cancer cell imaging. Chem Bio Chem, 13, 282-292.

    15. 15. Patra, M.C., Krishan, M., Kumar, C., Pasha, S., Chopra, M. (2012). Comparative modeling of human kappa opioid receptor and docking analysis with the peptide YFa. Journal of Molecular Graphics and Modelling, 33, 44-51.