Manisha Tiwari

Assistant Professor

Bio-Organic Chemistry Laboratory
Email: mtiwari07@gmail.com manisha_07@hotmail.com

Dr.Tiwari’s lab focuses on the synthesis of organic compounds for the treatment of diseases related to the cardiovascular system and diseases related to the central nervous system, using animal models

(i) The lab has worked extensively on the synthesis of novel sulphur containing compounds (analogs of diallyldisulfide, an active principle of garlic) for the treatment of hyperlipidemia. We have shown that these compounds inhibit the enzyme HMGR, the rate limiting enzyme in cholesterol biosynthesis. We have also gained some insight into the mechanism of action opf these compounds. We are now developing new analogs of diallyldisulfide for the treatment of hypertension. Preliminary results show that these compound could be useful in the treatment of hypertension

(ii) Their lab has also synthesized certain novel aryl piperazines and has shown them to be agonists/partial agonists for the 5-HT1A receptors. Pharmacological evaluation of these compounds demonstrated that these compounds showed anxiolytic like activity, mediated via the 5-HT1A receptors

Dr. Tiwari is working on the treatment of certain diseases using extracts/active principles of natural products

(i) Dr. Tiwari and her students have used extracts of the plant Convolvulus pluricaulis for their neuroprotective role against aluminium chloride induced neurotoxicity in rat cerebral cortex. These extracts have shown to have neuroprotective potential, thus validating their role in alleviating toxic effects of aluminium

(ii) The cytotoxic and antioxidant effects of the bark of Acacia catechu were studied using methanolic and aqueous extracts. An active principle of the compound was isolated and characterized and both the extract and the active principle were shown to be good antioxidants with cytotoxic activity The active principle elicited an 87% inhibition of the oral cancer cell line KB.

Honours and awards:

INSA visiting fellowship, 2004

Ongoing Projects:
  1. “An evaluation of the Anxiolytic activity of some novel aryl piperazine derivatives”, funded by University of Delhi, 2008-2011.

Selected Recent Publications:
  1. 1. Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME –induced hypertension.
    Dinesh Sharma, Apra Manral, Vikas Saini, Avninder Singh, BP Srinivasan and Manisha Tiwari
    European Journal of Pharmacology ; 691, 198-208 ,2012

  2. 2. In vitro cytotoxic activity of methanolic extract of the bark of Acacia catechu against human oral and lung cancer cell lines Sameena Alam, Manisha Khatri and Manisha Tiwari Journal of Pharmacy Research ,5(8), 4487-4491, 2012

  3. 3. Synthesis and Pharmacological Evaluation of [(4-Arylpiperazin-1-yl)-alkyl]-carbamic Acid Ethyl Ester Derivatives as Potential Anxiolytic Agents Manisha Khatri, Santosh Kumar Rai, Ranjit Ranbhor, Krishna Kishore, Manisha Tiwari Archives of Pharmacal Research, 35(7), 1143-1152, 2012

  4. 4. In vivo investigation of the neuroprotective property of Convolvulus pluricaulis in scopolamine-induced cognitive impairments in Wistar rats Syed Waseem Bihaqi, Avninder Pal Singh, Manisha Tiwari Indian Journal of Pharmacology, 43, 520-525, 2011

  5. 5. Neuroprotective role of Convolvulus Pluricaulis on aluminium induced neurotoxicity Syed Waseem Bihaqi, Meenakshi Sharma, Avninder Pal Singh, Manisha Tiwari Journal of Ethnopharmacology ,124 (3),409-415, 2009

  6. 6. Inhibitory effect of novel diallyldisulphide analogs on HMG-CoA reductase expression in hypercholesterolemic rats:CREB as a potential upstream target Santosh Kumar Rai, Meenakshi Sharma and Manisha Tiwari Life Sciences ,85, 211-219,2009

  7. 7. Synthesis and pharmacological evaluation of new aryl piperazines N-{4-[4-(aryl) piperazine-1-yl]-amine derivatives: Putative role of 5HT1A receptors Manisha Khatri, Santosh Kumar Rai, Sameena Alam, Anjana Vij, Manisha Tiwari Bioorganic & Medicinal Chemistry 17,1890-1897 ,2009 .

  8. 8. Synthesis, DNA binding and cytotoxic evaluation of new analogs of Diallyldisulfide, an active principle of garlic Santosh Kumar Rai, Meenakshi Sharma and Manisha Tiwari Bioorganic & Medicinal Chemistry, 16, 7301-7309, 2008

  9. 9. Effect of NO modualtors on cardiovascular risk factors in mild hyperhomocysteinemic rat model. Meenakshi Sharma, Santosh Kumar Rai, Manisha Tiwari and Ramesh Chandra Basic Clinical Pharmacology and Toxicology, 103 (1), 25-30, 2008

  10. 10. The effects of the aqueous extract of the roots of Asparagus racemosus on hepatocarcinogenesis initiated by Diethylnitrosamine Alka Agrawal, Meenakshi Sharma, Santosh Kumar Rai, Bharat Singh, Manisha Tiwari and Ramesh Chandra Phytotherapy Research ,22 (9), 1175-1182, 2008