Faculty


Sanjay Kumar Dey

Assistant Professor

Structural Biology, Systems Biology and Molecular Medicine
Email: sanjaydey23@gmail.com

Dr. Sanjay Kumar Dey, is currently anAssistant Professor at the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, building the Laboratory for Structural Biology, Systems Biology, and Molecular Medicine. He obtained his Doctoral Degree in 2017 from the University of Delhi South Campus, New Delhi, India. Dr. Deyworked at the Hamburg University and the DeutschesElektronen-Synchrotron (DESY), Hamburg, Germany as a visiting Research Scholar (2015) and at the Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, India as an Assistant Professor (2016-2017). Later, he worked as a Research Associate (2017-2019) at the University of Delhi South Campus. He then joined the Center for Advanced Biotechnology and Medicine (CABM), the Rutgers University, U.S.A. where he worked as a Post-doctoral Associate (2019-2021).

Dr. Dey joined the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi as an Assistant Professor in 2021.

He has received several awards and scholarships including Prof. RatnaPhadke Young Scientist Award 2013 (by IBS, India); CHAMP Mentee 2015 of the Council on Hypertension of the American Heart Association, USA; International Society for Hypertension-United Kingdom Research Fellow since 2016 (by the ISH, UK); Prof. Devendra K. Agrawal Young Investigator Award 2018 (by the International Academy for Cardiovascular Research (Indian Section), India etc. for his outstanding contribution in the field of anti-hypertensive and anti-cardiac hypertrophic drug discovery using structure-based approaches. He also received'the Boehringer Ingelheim Fonds award 2015 for Basic Research in Medicine' to pursue research at the Hamburg University, Germany (by the Boehringer Ingelheim Fonds, Germany). Dr. Dey has significantly contributed to the field of structure-based drug discovery against hypertension, cardiac-hypertrophy and his phenomenal research findings facilitated by biophysical, biochemical techniques and animal model systems, has resulted into two published patents (201811005899A and 201711036983A) and many high-impact research papers. Buoyed by his expertise in the fields of structural biology and protein biochemistry, he has accomplished his postdoctoral research work by expressing, purifying, characterizing and solving cryo-EM structures of challenging HIV and SARS-CoV-2 proteins and polyproteins in Prof. Eddy Arnold's lab at CABM, Rutgers University, U.S.A.

Ongoing Research, Dr. Dey and his research team are involved in exploringcardio-metabolic syndrome (complex interconnected human disorders dealing with hypertension-obesity-diabetes-gastro-intestinal abnormalities) using a multi-OMICS Systems Biology approach with the help of patient samples, cell culture, and animal model-dependent experiments. His lab is also involved in investigating the p53 dependent mechanisms to regulate neoplastic pathways using structure biology and transcriptomic approaches. Another research study involves crystallographic and/or cryo-EM structure-based drug discoveryagainst viral disorders including dengue, and SARS-CoV-2 etc.

Honours & Awards:

  1. 1. Prof.RatnaPhadke Young Scientist Award 2013 by the Indian Biophysical Society.

  2. 2. Prof. Devendra K. Agrawal Young Investigator Award 2018 by the International Academy for Cardiovascular Research (Indian Section).

  3. 3. Boehringer Ingelheim Fonds travel award 2015 for basic research in medicine to pursue research at the Hamburg University, Germany, by the Boehringer Ingelheim Fonds, Germany.

  4. 4. Awarded "the International Society for Hypertension-United Kingdom Research Fellow" since 2016, by the International Society of Hypertension, UK.

  5. 5. Awarded the CHAMP Mentee 2015 of the Council on Hypertension of the American Heart Association, USA

  6. 6. Professor Atul Chandra Biswas Memorial Award 2009 as Best All-round Academic Performer among the P.G. Students of Presidency College, Kolkata.

  7. 7. Professor Sivotosh Mukherjee Memorial Award 2009 for securing highest marks in M.Sc. in Molecular Biology and Genetics in Presidency College, Kolkata.

  8. 8. Govt. Eden Hindu Hostel Excellence Award 2008 for securing highest marks in M.Sc. among all subjects in the Govt. Eden Hindu Hostel of Presidency College, Kolkata.

  9. 9. Professor Hemendra Nath Mukherjee Memorial Medal 2007 for securing highest marks among all sterams of Bio-science in Ananda Mohan College, Kolkata.

  10. 10. UGC sponsored JRF and SRF (CSIR-UGC NET)during 2011-2015

  11. 11. DST INSPIRE Fellowship for pursuing PhD, December, 2010.

  12. 12. DBT, GoI Sponsored Traineeship for working in Bioinformatics during 2009-2010.

  13. 13. International travel grants from the DBT, DST-SERB, CSIR, ICMR, INSA-CSIR-DAE/BRNS-CICS, Immunology foundation, India and theAmerican Society for Biochemistry and Molecular Biology, USA etc. during 2013-2015

Patents:

  1. 1. "Kundu, S., S. K. Dey, B. Thelma, G. Kovuru, P. Prabhakar, and M. Saini. "An anti-hypertensive cardioprotective composition." Indian Patent under examination (2018). 201811005899

  2. 2. "Kundu, S., B. Thelma, S. Maulik, P. Prabhakar, and S. K. Dey. "Novel anti-hypertensive and anti-cardiac hypertrophic compounds." Indian Patent under examination (2017). 201711036983

Selected Recent Publications:
  1. 1. Dey JK, Dey SK. SARS-CoV-2 Pandemic, COVID-19 Case Fatality Rates and Deaths per Million Population in India. Journal of Bioinformatics, Computational and Systems Biology. 2021; 2(1):110.

  2. 2. Dey SK, Bhaduri S, Midya T. An analysis on the divergence of Chironomid spp. based on the study of 18S rRNA and polytene chromosome organisation in the species revealing the role of environment on speciation.The Journal of Basic and Applied Zoology (Under 2nd Revision),2021.

  3. 3. Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh AS, Anand V, Das HK, Kundu S. Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with similar interaction energy as Remdesivir-triphosphate, indicating potential in the treatment of Covid-19 infection. J. Biomolecular Structure & Dynamics; Under revision). 2021, Preprint server DOI:10.31219/osf.io/urxwh

  4. 4. Pandey AK, Saxena A, Dey SK, Kanjilal M, Kumar U, Thelma B K. Detection of ARL15 in human sera and its genotype-phenotype correlation in Rheumatoid arthritis. Journal of Genetics (In press) 2021.

  5. 5. Dey JK*, Dey SK* and Sihag H. Current Insights into the Novel Coronavirus Disease 2019 (COVID-19) and Its Homoeopathic Management. Homoopathic Links, 2020; 33(03):171-181. DOI: https://doi.org/10.1055/s-0040-1715636. *Equal contributions.

  6. 6. Kumar P, Nag TC, Jha KA, Dey SK, Kathpalia P, Maurya M, Gupta CL, Bhatia J, Roy TS, Wadhwa S. Experimental oral iron administration: Histological investigations and expressions of iron handling proteins in rat retina with aging. Toxicology. 2017 Dec 1; 392:22-31

  7. 7. Punchaichira TJ, Dey SK, Mukhopadhyay A, Kundu S, Thelma BK. Characterization of SNPs in the dopamine-?-hydroxylase gene providing new insights into its structure-function relationship. Neurogenetics. 2017 Jul 1;18(3):155-68. https://doi.org/10.1007/s10048-017-0519-3

  8. 8. Jangir DK, Dey SK, Kundu S, Mehrotra R. Assessment of amsacrine binding with DNA using UV-visible, circular dichroism and Raman spectroscopic techniques. Journal of Photochemistry and Photobiology B: Biology. 2012 Sep 3; 114:38-43. https://doi.org/10.1016/j.jphotobiol.2012.05.005

  9. 9. Dey SK, Ganguli S, Roy P, Basu P, Chakraborty HJ and Datta A. Pseudoknots in Human snRNPs. Int. J. of Bioinformatics Research, 3(1): 194-199, (2011).

  10. 10. Ganguli S, Dey SK, Dhar P, Basu P, Roy P, Datta A. Catalytic RNA world relics in Dicer RNAs. International Journal of Genetics. 2010 Jan 1; 2(1):8.

  11. 11. Dey SK, Ganguli S, Basu P, Roy P, Datta A. Lysine richness in human snurps possible sites for electrophilic attacks. Bioinformation. 2010; 4(9):409.

  12. 12. Dey SK, Sarkar NK and Mukherjee TK. "A study of amylase activity in silk moth gut". Journal of Natural History (India), 5 (1): 41-45, (2009).