Faculty


Sanjay Kumar Dey

Assistant Professor

Structural Biology, Ion-channels and Molecular Medicine
Email: sdey@acbr.du.ac.in

Dr. Sanjay Kumar Dey, is currently anAssistant Professor at the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, building the Laboratory for Structural Biology, Systems Biology, and Molecular Medicine. He obtained his Doctoral Degree in 2017 from the University of Delhi South Campus, New Delhi, India. Dr. Deyworked at the Hamburg University and the DeutschesElektronen-Synchrotron (DESY), Hamburg, Germany as a visiting Research Scholar (2015) and at the Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, India as an Assistant Professor (2016-2017). Later, he worked as a Research Associate (2017-2019) at the University of Delhi South Campus. He then joined the Center for Advanced Biotechnology and Medicine (CABM), the Rutgers University, U.S.A. where he worked as a Post-doctoral Associate (2019-2021).

Dr. Dey joined the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi as an Assistant Professor in 2021.

He has received several awards and scholarships including Prof. RatnaPhadke Young Scientist Award 2013 (by IBS, India); CHAMP Mentee 2015 of the Council on Hypertension of the American Heart Association, USA; International Society for Hypertension-United Kingdom Research Fellow since 2016 (by the ISH, UK); Prof. Devendra K. Agrawal Young Investigator Award 2018 (by the International Academy for Cardiovascular Research (Indian Section), India etc. for his outstanding contribution in the field of anti-hypertensive and anti-cardiac hypertrophic drug discovery using structure-based approaches. He also received'the Boehringer Ingelheim Fonds award 2015 for Basic Research in Medicine' to pursue research at the Hamburg University, Germany (by the Boehringer Ingelheim Fonds, Germany). Dr. Dey has significantly contributed to the field of structure-based drug discovery against hypertension, cardiac-hypertrophy and his phenomenal research findings facilitated by biophysical, biochemical techniques and animal model systems, has resulted into two published patents (201811005899A and 201711036983A) and many high-impact research papers. Buoyed by his expertise in the fields of structural biology and protein biochemistry, he has accomplished his postdoctoral research work by expressing, purifying, characterizing and solving cryo-EM structures of challenging HIV and SARS-CoV-2 proteins and polyproteins in Prof. Eddy Arnold's lab at CABM, Rutgers University, U.S.A.

Ongoing Research, Dr. Dey and his research team are involved in exploring Ion-channels using a multi-OMICS Systems Biology approach with the help of patient samples, cell culture, and animal model-dependent experiments. His lab is also involved in investigating the p53/p73 dependent mechanisms to regulate neoplastic pathways using structureble biology (cryo-EM, XRD, and SAXS) and transcriptomic approaches. Another research study involves crystallographic and/or cryo-EM structure-based drug discoveryagainst viral disorders including dengue, and SARS-CoV-2 etc.

Vacant Research Positionsin the Structural Biology Lab:

  1. 1. Hard working and interested candidates who have their own fellowship are encouraged to apply for Ph.D. positions.

  2. 2. Experienced Ph.D. degree holders can apply for outstanding Postdoc positions under the IoE scheme, University of Delhi or other competitive post-doctoral fellowship programs in India.

Honours & Awards:

  1. 1. Prof.RatnaPhadke Young Scientist Award 2013 by the Indian Biophysical Society.

  2. 2. Prof. Devendra K. Agrawal Young Investigator Award 2018 by the International Academy for Cardiovascular Research (Indian Section).

  3. 3. Boehringer Ingelheim Fonds travel award 2015 for basic research in medicine to pursue research at the Hamburg University, Germany, by the Boehringer Ingelheim Fonds, Germany.

  4. 4. Awarded "the International Society for Hypertension-United Kingdom Research Fellow" since 2016, by the International Society of Hypertension, UK.

  5. 5. Awarded the CHAMP Mentee 2015 of the Council on Hypertension of the American Heart Association, USA

Selected Recent Publications:
  1. 1. Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh A S, Anand V, Das HK, and Kundu S. Suramin, Penciclovir and Anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics. November 2021. DOI: 10.1080/07391102.2021.2000498

  2. 2. Rizwan T, Kothidar A, Meghwani H, Sharma V, Shobhawat R, Saini R, Vaishnav HK, Singh V, Pratap M, Sihag H, Dey JK, Dey SK. Comparative analysis of SARS-CoV-2 envelope viroporin mutations from COVID-19 deceased and surviving patients revealed implications on its ion-channel activities and correlation with patient mortality. Journal of Biomolecular Structure and Dynamics. 2021 Jun 21:1-6. https://doi.org/10.1080/07391102.2021.1944319

  3. 3. Courouble VV*, Dey SK*, Yadav R*, Timm J, Harrison JJ, Ruiz FX, Arnold E, Griffin PR. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry. 2021 Jun 14. *co-first author

  4. 4. Dey SK, Bhaduri S, Midya T. An analysis on the divergence of Chironomid spp. based on the study of 18S rRNA and polytene chromosome organization in the species revealing the role of environment on speciation. The Journal of Basic and Applied Zoology. 2021 Dec; 82(1):1-2.

  5. 5. Pandey AK, Saxena A, Dey SK, Kanjilal M, Kumar U, Thelma BK. Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis. Journal of Genetics. 2021 Oct;100(2):1-6

  6. 6. Courouble VV, Dey SK, Yadav R, Timm J, Harrison JJ, Ruiz FX, Arnold E, Griffin PR. Resolving the dynamic motions of SARS-CoV-2 nsp7 and nsp8 proteins using structural proteomics. bioRxiv. 2021 Jan 1

  7. 7. Dey JK, Dey SK. SARS-CoV-2 Pandemic, COVID-19 Case Fatality Rates and Deaths per Million Population in India. Journal of Bioinformatics, Computational and Systems Biology. 2020; 2(1):110

  8. 8. Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh AS, Anand V, Das HK, Kundu S. Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with similar interaction energy as Remdesivir-triphosphate, indicating potential in the treatment of Covid-19 infection. JBSD (2020), Preprint server DOI: 10.31219/osf.io/urxwh

  9. 9. Dey JK, Dey SK and Pramanik A. A case of oligospermic male infertility successfully treated with personalized homoeopathic medicine Phosphoricum acidum. Homoopathic Links, 2020 (Accepted article, in press).

  10. 10. Dey JK*, Dey SK* and Sihag H. Current Insights into the Novel Coronavirus Disease 2019 (COVID-19) and Its Homoeopathic Management. Homoopathic Links, 2020; 33(03):171-181. DOI: https://doi.org/10.1055/s-0040-1715636. *Equal contributions.

  11. 11. Kumar P, Nag TC, Jha KA, Dey SK, Kathpalia P, Maurya M, Gupta CL, Bhatia J, Roy TS, Wadhwa S. Experimental oral iron administration: Histological investigations and expressions of iron handling proteins in rat retina with aging. Toxicology. 2017 Dec 1; 392:22-31

  12. 12. Punchaichira TJ, Dey SK, Mukhopadhyay A, Kundu S, Thelma BK. Characterization of SNPs in the dopamine-?-hydroxylase gene providing new insights into its structure-function relationship. Neurogenetics. 2017 Jul 1;18(3):155-68. https://doi.org/10.1007/s10048-017-0519-3

  13. 13. Jangir DK, Dey SK, Kundu S, Mehrotra R. Assessment of amsacrine binding with DNA using UV-visible, circular dichroism and Raman spectroscopic techniques. Journal of Photochemistry and Photobiology B: Biology. 2012 Sep 3; 114:38-43. https://doi.org/10.1016/j.jphotobiol.2012.05.005

  14. 14. Dey SK, Ganguli S, Roy P, Basu P, Chakraborty HJ and Datta A. Pseudoknots in Human snRNPs. Int. J. of Bioinformatics Research, 3(1): 194-199, (2011).

  15. 15. Dey SK, Ganguli S, Basu P, Roy P, and Datta, A. (2010). Lysine richness in human snurps possible sites for electrophilic attacks. Bioinformation, 4(9): 409

  16. 16. Ganguli S, Dey SK, Dhar P, Basu P, Roy P, Datta A. Catalytic RNA world relics in Dicer RNAs. International Journal of Genetics. 2010 Jan 1; 2(1):8

  17. 17. Dey SK, Sarkar NK and Mukherjee TK. "A study of amylase activity in silk moth gut". Journal of Natural History (India), 5 (1): 41-45, (2009)