Faculty


Sanjay Kumar Dey

Assistant Professor


Structural Biology of Membrane Proteins
Email: sdey@acbr.du.ac.in    Brife CV

Dr. Sanjay Kumar Dey, is currently an Assistant Professor at the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, building the Laboratory for Structural Biology, Systems Biology, and Molecular Medicine. He obtained his Doctoral Degree in 2017 from the University of Delhi South Campus, New Delhi, India. Dr. Dey worked at the Hamburg University and the Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany as a visiting Research Scholar (2015) and at the Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, India as an Assistant Professor (2016-2017). Later, he worked as a Research Associate (2017-2019) at the University of Delhi South Campus. He then joined the Center for Advanced Biotechnology and Medicine (CABM), the Rutgers University, U.S.A. where he worked as a Post-doctoral Associate (2019-2021).

Dr. Dey joined the Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi as an Assistant Professor in 2021.

He has received several awards and scholarships including Prof. Ratna Phadke Young Scientist Award 2013 (by IBS, India); CHAMP Mentee 2015 of the Council on Hypertension of the American Heart Association, USA; International Society for Hypertension-United Kingdom Research Fellow since 2016 (by the ISH, UK); Prof. Devendra K. Agrawal Young Investigator Award 2018 (by the International Academy for Cardiovascular Research (Indian Section), India etc. for his outstanding contribution in the field of anti-hypertensive and anti-cardiac hypertrophic drug discovery using structure-based approaches. He also received 'the Boehringer Ingelheim Fonds award 2015 for Basic Research in Medicine' to pursue research at the Hamburg University, Germany (by the Boehringer Ingelheim Fonds, Germany). Dr. Dey has significantly contributed to the field of structure-based drug discovery against hypertension, cardiac- hypertrophy and his phenomenal research findings facilitated by biophysical, biochemical techniques and animal model systems, has resulted into six patents so far (201811005899A, 201711036983A, 202111036665, 202111026777, 202111026998, 202121026835) and many high-impact research papers. Buoyed by his expertise in the fields of structural biology and protein biochemistry, he has accomplished his postdoctoral research work by expressing, purifying, characterizing and solving cryo-EM structures of challenging HIV and SARS-CoV-2 proteins and polyproteins in Prof. Eddy Arnold's lab at CABM, Rutgers University, U.S.A.

Ongoing Research, Dr. Dey and his research team are involved in exploring membrane proteins including ion-channels, GPCRs, transmembrane receptors using a multi-OMICS Systems Biology approach with the help of patient samples, cell culture, and animal model-dependent experiments. His lab is also involved in investigating the p53/p73 dependent mechanisms to regulate neoplastic pathways using structural biology (cryo-EM, XRD, and SAXS) and transcriptomic approaches. Another research study involves crystallographic and/or cryo-EM structure-based drug discovery against viral disorder like COVID-19. His. Lab is also. Involved in working with atherosclerosis.

Vacant Research Positionsin the Structural Biology Lab:

  1. Hard working and interested candidates who have their own fellowship are encouraged to apply for Ph.D. or JRF positions.

ONGOING PROJECTS:

  1. 01. Structural-functional characterization of human ... ion-channel protein to decipher its role in atherosclerosis for therapeutic intervention. Funding Agency: Indian Council of Medical Research (ICMR), GoI; Grant Amount: 31.98 lakhs

  2. 02. Mechanistic investigation of human receptors to decipher their roles in hypertension and atherosclerosis associated cardiovascular disorders for therapeutic intervention (CRG/2023/007380). Funding Agency: SERB, ANRF, GoI; Grant Amount: 60 lakhs

  3. 03. Silicon-to-Lead: Using AI Tools to Accelerate the Design, Synthesis and Development of New Drugs to Combat Cardiovascular Diseases. Funding Agency: BITS-Pilani, GoI; Grant Amount: 28 lakhs

Patents:

  1. 1. A Sensitive, Cost-Effective and Non-Hazardous Method of Chromosome Staining. (IN 202111036665)

  2. 2. Novel Anti-Hypertensive Cardioprotective composition compromising of DISPIRO [1H-PERIMIDINE-2(3H), 2" (3"H)-[1H] PERIMIDINE. (IN202111026998)

  3. 3. A Furan-based anti-rheumatoid arthritis composition. (IN202121026835)

  4. 4. Quinolone-based anti-hypertensive cardioprotective composition. (IN202111026777)

  5. 5. An anti-hypertensive cardioprotective composition. (IN 201811005899)

  6. 6. Novel anti-hypertensive and anti-cardiac hypertrophic compounds. (IN201711036983)

Selected Recent Publications:
  1. 01. Das, S., Nath, S. and Dey, S.K., 2024. Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication. DARU Journal of Pharmaceutical Sciences, pp.1-23.

  2. 02. Rani, D., Kaur, S., Dey, J.K. and Dey, S.K., 2024. Engineering immune response to regulate cardiovascular disease and cancer. Advances in Protein Chemistry and Structural Biology, 140, pp.381-417.

  3. 03. Shahjahan, Joy Kumar Dey, Sanjay Kumar Dey. (2023). Competitive binding of ribavirin, velpatasvir, and remdesivir to the active site of DNA polymerase can make them repurposable drugs to combat Monkeypox. International Journal of Scientific Development and Research, 8(10), 771-784. https://doi.org/10.5281/zenodo.10676365, Impact Factor: 8.15

  4. 04. Saini, M., Upadhyay, N., Dhiman, K., Manjhi, S.K., Kattuparambil, A.A., Ghoshal, A., Arya, R., Dey, S.K., Sharma, A., Aduri, R. Thelma, B.K., Kundu S. 2024. ARL15, a GTPase implicated in rheumatoid arthritis, potentially repositions its truncated N-terminus as a function of guanine nucleotide binding. International Journal of Biological Macromolecules, 254, p.127898.Impact Factor: 8.2

  5. 05. ShreetamaBandyopadhayaya, Pooja Yadav, Ankit Sharma, Sanjay Kumar Dey, Alo Nag, Rekha Maheshwari, Bridget M. Ford, Chandi C. Mandal (16-05-2023). Oncogenic role of an uncharacterized cold-induced zinc finger protein 726 in breast cancer. J of Cellular Biochemistry. 124(6), 889-906;https://doi.org/10.1002/jcb.30417, Impact Factor: 4.48

  6. 06 Dey, S.K., Kumar, S., Rani, D., Maurya, S.K., Banerjee, P., Verma, M. and Senapati, S., 2023. Implications of vitamin D deficiency in systemic inflammation and cardiovascular health. Critical Reviews in Food Science and Nutrition, pp.1-18, https://doi.org/10.1080/10408398.2023.2224880, Impact Factor: 11.2

  7. 07. Yadav R, Courouble VV, Dey SK, Harrison JJEK, Timm J, Hopkins JB, Slack RL, Sarafianos SG, Ruiz FX, Griffin PR, and Arnold E (2022). Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science Advances, (under review, ID: add2191; 2022), Impact Factor: 14.96

  8. 08. Far BF, Bokov D, Widjaja G, Budi HS, Abdelbasset WK, Javanshir S, Seif F, Pazoki-Toroudi H, and Dey SK (2022). Metronidazole, acyclovir and tetrahydrobiopterin may be promising to treat COVID-19 patients, through interaction with interleukin-12, Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2022.2064917, Impact Factor: 5.24

  9. 09. Courouble VV*, Dey SK*, Yadav R*, Timm J, Harrison JJ, Ruiz FX, Arnold E, Griffin PR. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry. (2021) *co-first author. https://doi.org/10.1021/jasms.1c00086, Impact Factor: 3.26

  10. 10. Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh A S, Anand V, Das HK, and Kundu S. Suramin, Penciclovir and Anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics. (2021) https://doi.org/10.1080/07391102.2022.2064917, Impact Factor: 5.24

  11. 12. Rizwan T, Kothidar A, Meghwani H, Sharma V, Shobhawat R, Saini R, Vaishnav HK, Singh V, Pratap M, Sihag H, Dey JK, and Dey SK. Comparative analysis of SARS-CoV-2 envelope viroporin mutations from COVID-19 deceased and surviving patients revealed implications on its ion-channel activities and correlation with patient mortality. Journal of Biomolecular Structure and Dynamics. (2021) 21:1-6. https://doi.org/10.1080/07391102.2021.1944319, Impact Factor: 5.24

  12. 13. Dey SK, Bhaduri S, and Midya T. An analysis on the divergence of Chironomid spp. based on the study of 18S rRNA and polytene chromosome organization in the species revealing the role of environment on speciation. The Journal of Basic and Applied Zoology. (2021); 82(1):1-2. https://doi.org/10.1186/s41936- 021-00215-0, Impact Factor: 1

  13. 14. Pandey AK, Saxena A, Dey SK, Kanjilal M, Kumar U, Thelma BK. Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis. Journal of Genetics. (2021) 100(2):1-6. https://doi.org/10.1007/s12041-021-01286-2, Impact Factor: 1.5

  14. 15. Dey JK, Dey SK. SARS-CoV-2 Pandemic, COVID-19 Case Fatality Rates and Deaths per Million Population in India. Journal of Bioinformatics, Computational and Systems Biology. (2020); 2(1):110, Impact Factor: 1

  15. 16. Dey JK*, Dey SK* and Sihag H. Current Insights into the Novel Coronavirus Disease 2019 (COVID-19) and Its Homoeopathic Management. Homoopathic Links, (2020); 33(03):171-181. DOI: https://doi.org/10.1055/s-0040-1715636 . *Equal contributions, Impact Factor: 1

REVIEW ARTICLES

  1. 1. Choudhury, SP, Bano, S, Sen, S, .. Dey SK* and Sharma V., 2022. Altered Neural Cell Junctions and Ion- channels Leading to Disrupted Neuron Communication: Some Novel Perspectives in the Spread of Parkinson's Disease. NPG Parkinson's Disease. *Corresponding author, https://www.nature.com/articles/s41531-022-00324-9, Impact Factor: 9.3

  2. 2. Kumar, G.*, Dey, S.K.* and Kundu, S., 2021. Corrigendum to Herbs and their bioactive ingredients in cardio-protection: underlying molecular mechanisms and evidences from clinical studies. Phytomedicine, p.153753.*equal contribution. https://doi.org/10.1016/j.phymed.2021.153828, Impact Factor: 6.66

  3. 3. Kumar, G.*, Dey, S.K.* and Kundu, S., 2021. Herbs and their bioactive ingredients in cardio-protection: underlying molecular mechanisms and evidences from clinical studies. Phytomedicine, p.153753. *equal contribution. https://doi.org/10.1016/j.phymed.2021.153753, Impact Factor: 6.66

  4. 4. Dey SK, Saini M, Prabhakar P, and Kundu S. Dopamine ? hydroxylase as a potential drug target to combat hypertension. Expert Opinion on Investigational Drugs. 2020; 29(9):1043-1057. https://doi.org/10.1080/13543784.2020.1795830, Impact Factor: 6.5

  5. 5. Kumar G, Dey SK, and Kundu S. Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions. Life Sciences, Volume: 259, article number: 118377, DOI: https://doi.org/10.1016/j.lfs.2020.118377 (2020), Impact Factor: 6.78

  6. 6. Dey, JK, Mukherjee A, Dey SK, Pramanik A, Giri S, and Pratap M. "A systematic review on the efficacies and therapeutic interventions of homoeopathic medicines in combating viral disorders with implications in the currently undergoing homoeopathic treatment efforts of SARS-CoV-2 infection (COVID-19)."International Journal of High Dilution Research, 19 (3): 27-39 (2020). https://doi.org/10.1016/j.tox.2017.10.005, Impact Factor: 1

BOOK CHAPTERS

  1. 01. Diksha Rani, Smaranjot Kaur, Shahjahan, Joy Kumar Dey, Sanjay Kumar Dey. Engineering immune response to regulate cardiovascular disease and cancer. Advances in Protein Chemistry and Structural Biology. DOI: https://doi.org/10.1016/bs.apcsb.2023.12.004, Impact Factor: 5.4

  2. 02. Shahjahan, Dey JK, Dey SK. Translational bioinformatics approach to combat cardiovascular disease and cancers. Advances in Protein Chemistry and Structural Biology. 2024;139:221-261. https://doi.org/10.1016/bs.apcsb.2023.11.006. Impact Factor: 5.4

  3. 03. Shahjahan, Sanjay Kumar Dey, Chapter 9 - Role of miRNA in monkeypox viral diagnosis and therapeutic developments,Editor(s): Vijay Kumar Prajapati, Rupal Ojha,MicroRNA in Human Infectious Diseases, Academic Press, 2024, Pages 201-219, ISBN 9780323996617, https://doi.org/10.1016/B978-0-323-99661-7.00002-3.

  4. 04. Kumar, G*, Dey, S.K.*, and Kundu, S. (2023). Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics. In: Ray, A., Gulati, K. (eds) Nitric Oxide: From Research to Therapeutics. Advances in Biochemistry in Health and Disease, vol 22. Springer, Cham. *Equal contributions. https://doi.org/10.1007/978-3-031-24778-1_3

  5. 05. Dey JK, Ahmedi, S, Jain, N, Bano, S, Manzoor N, and Dey SK. Effect of the Changing Climate and Urban Ecology on Spreading of Infectious Diseases Including SARS-CoV-2. In: Bhadouria, R, Upadhyay, S, Tripathi, S and Singh, P (eds.) Urban Ecology and Global Climate Change. John Wiley & Sons Limited, located at The Atrium, Southern Gate, West Sussex PO19 8SQ, United Kingdom. (2022) ISBN: 9781119807186, https://doi.org/10.1002/9781119807216.ch12

  6. 06. Choudhury, SP, Arora, A, Jain, J. and Dey SK. Climate change, urbanization and their impact on increased occurrence of cardiometabolic syndrome. In: Bhadouria, R, Upadhyay, S, Tripathi, S and Singh, P (eds.) Urban Ecology and Global Climate Change. John Wiley & Sons Limited, located at The Atrium, Southern Gate, West Sussex PO19 8SQ, United Kingdom. (2022) ISBN: 9781119807186, https://doi.org/10.1002/9781119807216.ch2

  7. 07. Dey SK, Senapati S. (2021) Insulin and Insulin-Like Growth Factor-1 Associated Cancers. In: Kumar S., Gupta S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_3

  8. 08. Dey SK, Senapati S. (2021) In Vivo Models for Obesity and Obesity Related Carcinogenesis. In: Kumar S., Gupta S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_14

  9. 09. Kundu S, Saini M, Dey SK, Kundu S. Dopamine Beta Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases. In Frontiers in Protein Structure, Function, and Dynamics 2020 (pp. 339-357). Springer, Singapore. https://doi.org/10.1007/978-981-15-5530-5_14

  10. 10. Kumar G*, Dey SK*, and Kundu S. Nitric oxide and cardiovascular diseases: Cardio protection, Complications and Therapeutics. 2022. Springer Nature, Singapore (Accepted) (2022) *Equal contributions.