Faculty


Sanjay Kumar Dey

Assistant Professor


Structural Biology of Membrane Proteins
Email: sdey@acbr.du.ac.in    Weblink: My Lab

Dr. Sanjay Kumar Dey is an Assistant Professor in Biomedical Sciences at the Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi, where he leads the Laboratory for Structural Biology of Proteins. He obtained his Ph.D. in Biochemistry (2017) from the University of Delhi South Campus, where his research focused on the structural and functional characterization of dopamine ?-hydroxylase, cytochrome b5 reductase 3 in cardiovascular homeostasis. He pursued postdoctoral training at the Center for Advanced Biotechnology and Medicine (CABM), Rutgers University, USA (2019-2021), where he worked on the biochemical and structural elucidation of HIV and SARS-CoV-2 proteins and polyproteins using single particle cryo-electron microscopy. Earlier, Dr. Dey served as an Assistant Professor at the Central University of Rajasthan (2016-2017) and as a Research Associate (2017-2019) at the University of Delhi South Campus. He was also a Visiting Research Scholar (2015) at the University of Hamburg and DeutschesElektronen-Synchrotron (DESY), Germany, supported by the Boehringer Ingelheim Fonds Award for Basic Research in Medicine to work with structural biology technologies like Synchrotron, XFEL etc.

Dr. Dey has received several prestigious awards, including the Prof. Ratna Phadke Young Scientist Award (2013), Prof. Devendra K. Agrawal Young Investigator Award (2018), and multiple international travel and other fellowships from the ICMR, DBT, DST, CICS, and CSIR. He has been recognized as an International Society of Hypertension (UK) Research Fellow since 2016. His group's research on structure-based drug discovery and method developments have led to ten Indian patents (IN 201711036983, IN 201811005899, IN 202111026777, IN 202111026998, IN 202111036665, IN 202121026835, IN 202411007373, IN 202411059481, IN 202511102200, and IN 202511089336) and numerous high-impact international publications in cardiovascular biology.

Ongoing Research, Dr. Dey and his research team involvedin the structural and functional characterization of membrane proteins, ion channels, and GPCRs using advanced techniques such as single particle cryo-EM, X-ray crystallography, SAXS, and XL-MS.Dey lab integrates biochemical, biophysical, and multi-omics approaches with patient-derived, cellular, and animal models to understand mechanisms underlying cardiovascular disorders, especially atherosclerosis and hypertension. The group routinely employs AKTA FPLC for protein purification and electrophysiology for functional studies. Equipped with facilities for rodent NIBP, ECG, EMG, EEG, and SpO? monitoring.Dey lab regularly works with rat and mice models of hypertension, atherosclerosis, and cardiac hypertrophy.

ONGOING PROJECTS:

  1. 01. Structural-functional characterization of human ... ion-channel protein to decipher its role in atherosclerosis for therapeutic intervention. Funding Agency: Indian Council of Medical Research (ICMR), GoI; Grant Amount: 31.98 lakhs

  2. 02. Mechanistic investigation of human receptors to decipher their roles in hypertension and atherosclerosis associated cardiovascular disorders for therapeutic intervention (CRG/2023/007380). Funding Agency: SERB, ANRF, GoI; Grant Amount: 52.4 lakhs

  3. 03. Investigation of human GPCR to decipher its role in breast cancer for therapeutic application. IoE-DU; Grant Amount: 21 Lakhs (5 L + 5 L + 6 L + 6 L)

COMPLETED PROJECTS:

  1. 01. Silicon-to-Lead: Using AI Tools to Accelerate the Design, Synthesis and Development of New Drugs to Combat Cardiovascular Diseases. Funding Agency: BITS-Pilani, GoI; Grant Amount: 28 lakhs

  2. 02. Biophysical, biochemical, and electrophysiological evaluation of therapeutically important Envelope, ORF3a, and ORF7a proteins of SARS-CoV-2. IoE-DU, Funding amount: 3 Lakhs

Patents:

  1. 1. Mesoporous Bioactive Glass Nanoparticles, Process for Preparation and Biomedical Devices Comprising (IN 202511089336)

  2. 2. Cannabidiol-Loaded Mesenchymal Stem Cell-Derived Exosome Composition and Process for its Preparation (IN 202511102200)

  3. 3. Triazole-based Anti-breast Cancer Agent Formulation and a Method for Preparing Thereof (IN 202411059481)

  4. 4. Biologically Active Anti-Cancer Compound and Derivative Thereof, and Green Synthesis Thereof (IN 202411007373)

  5. 5. A Sensitive, Cost-Effective and Non-Hazardous Method of Chromosome Staining (IN 202111036665)

  6. 6. Quinolone-Based Anti-Hypertensive Cardio-Protective Composition (IN 202111026777)

  7. 7. Novel Anti-Hypertensive Cardioprotective Composition Comprising of Dispiro[1H-Perimidine-2(3H),2''(3''H)-[1H]Perimidine (IN 202111026998)

  8. 8. A Furan-Based Anti-Rheumatoid Arthritis Composition (IN 202121026835)

  9. 9. An Anti-Hypertensive Cardio-Protective Composition (IN 201811005899)

  10. 10. Novel Anti-Hypertensive and Anti-Cardiac Hypertrophic Compounds (IN 201711036983)

Selected Recent Publications:
  1. 01. Bano, S., Singh, J., Zehra, Z., Sulaimani, M.N., Mohammad, T., Yumlembam, S., Hassan, M.I., Islam, A. and Dey, S.K., 2025. Biochemical Screening of Phytochemicals and Identification of Scopoletin as a Potential Inhibitor of SARS-CoV-2 Mpro, Revealing Its Biophysical Impact on Structural Stability. Viruses, 17(3), p.402. https://doi.org/10.3390/v17030402 Impact Factor: 3.5

  2. 02. Zehra, Z., Bano, S., Hasan, Z., Choudhir, G., Shamsi, A., Shahwan, M., Dey, S.K. and Islam, A., 2025. Inhibitory potential of gallic acid against SARS-CoV-2 main protease: A structure-function insight using combined spectroscopic and computational approach. Journal of Molecular Liquids, p.128007. https://doi.org/10.1016/j.molliq.2025.128007 Impact Factor: 5.2

  3. 03. Bandyopadhayaya S, Yadav P, Kumari M, Dey SK, Mandal CC. Multifaceted in Silico Screening Strategies Identifies Potent Inhibitors Facilitating Inhibition of ZNF726 Activity in Breast Cancer. Chemical Biology & Drug Design 2025; 105: e70144. https://doi.org/10.1111/cbdd.70144 Impact Factor: 2.5

  4. 04. Rani, U., Matlovicova, K., Pandey, B.W., Vaishnav, H.K., Saini, R., Dey, S.K., Gozner, M., Bujdoso, Z., & Mishra, P.K. (2025). Informal urban livelihoods and environmental inequality: Occupational health risks among waste pickers in Ghaziabad, India. Geojournal of Tourism and Geosites, 61(3), 1859-1874. Impact Factor: 1

  5. 05. Shahjahan, Joy Kumar Dey, Sanjay Kumar Dey. (2023). Competitive binding of ribavirin, velpatasvir, and remdesivir to the active site of DNA polymerase can make them repurposable drugs to combat Monkeypox. International Journal of Scientific Development and Research, 8(10), 771-784. https://doi.org/10.5281/zenodo.10676365, Impact Factor: 8.15

  6. 06 Saini, M., Upadhyay, N., Dhiman, K., Manjhi, S.K., Kattuparambil, A.A., Ghoshal, A., Arya, R., Dey, S.K., Sharma, A., Aduri, R. Thelma, B.K., Kundu S. 2024. ARL15, a GTPase implicated in rheumatoid arthritis, potentially repositions its truncated N-terminus as a function of guanine nucleotide binding. International Journal of Biological Macromolecules, 254, p.127898. Impact Factor: 8.2

  7. 07. ShreetamaBandyopadhayaya, Pooja Yadav, Ankit Sharma, Sanjay Kumar Dey, Alo Nag, Rekha Maheshwari, Bridget M. Ford, Chandi C. Mandal (16-05-2023). Oncogenic role of an uncharacterized cold-induced zinc finger protein 726 in breast cancer. J of Cellular Biochemistry. 124(6), 889-906; https://doi.org/10.1002/jcb.30417, Impact Factor: 4.48

  8. 08. Yadav R, Courouble VV, Dey SK, Harrison JJEK, Timm J, Hopkins JB, Slack RL, Sarafianos SG, Ruiz FX, Griffin PR, and Arnold E (09-12-2022). Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science Advances, DOI: http://dx.doi.org/10.1126/sciadv.add2191, Impact Factor: 14.14

  9. 09. Far BF, Bokov D, Widjaja G, Budi HS, Abdelbasset WK, Javanshir S, Seif F, Pazoki-Toroudi H, and Dey SK (2022). Metronidazole, acyclovir and tetrahydrobiopterin may be promising to treat COVID-19 patients, through interaction with interleukin-12, Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2022.2064917 , Impact Factor: 5.24

  10. 10. Courouble VV*, Dey SK*, Yadav R*, Timm J, Harrison JJ, Ruiz FX, Arnold E, Griffin PR. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry. (2021) *co-first author. https://doi.org/10.1021/jasms.1c00086 , Impact Factor: 3.26

  11. 12. Dey SK, Saini M, Dhembla C, Bhatt S, Rajesh A S, Anand V, Das HK, and Kundu S. Suramin, Penciclovir and Anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics. (2021) https://doi.org/10.1080/07391102.2021.2000498 , Impact Factor: 5.24

  12. 13. Rizwan T, Kothidar A, Meghwani H, Sharma V, Shobhawat R, Saini R, Vaishnav HK, Singh V, Pratap M, Sihag H, Dey JK, and Dey SK. Comparative analysis of SARS-CoV-2 envelope viroporin mutations from COVID-19 deceased and surviving patients revealed implications on its ion-channel activities and correlation with patient mortality. Journal of Biomolecular Structure and Dynamics. (2021) 21:1-6. https://doi.org/10.1080/07391102.2021.1944319 , Impact Factor: 5.24

  13. 14. Dey SK, Bhaduri S, and Midya T. An analysis on the divergence of Chironomid spp. based on the study of 18S rRNA and polytene chromosome organization in the species revealing the role of environment on speciation. The Journal of Basic and Applied Zoology. (2021); 82(1):1-2. https://doi.org/10.1186/s41936-021-00215-0 , Impact Factor: 1

  14. 15. Pandey AK, Saxena A, Dey SK, Kanjilal M, Kumar U, Thelma BK. Correlation between an intronic SNP genotype and ARL15 level in rheumatoid arthritis. Journal of Genetics. (30-04-2021) 100(2):1-6. https://doi.org/10.1007/s12041-021-01286-2 , Impact Factor: 1.5

  15. 16. Dey JK, Dey SK. SARS-CoV-2 Pandemic, COVID-19 Case Fatality Rates and Deaths per Million Population in India. Journal of Bioinformatics, Computational and Systems Biology. (2020); 2(1):110, Impact Factor: 1

REVIEW ARTICLES

  1. 1. Choudhury, SP, Bano, S, Sen, S, .. Dey SK* and Sharma V., 2022. Altered Neural Cell Junctions and Ion- channels Leading to Disrupted Neuron Communication: Some Novel Perspectives in the Spread of Parkinson's Disease. NPG Parkinson's Disease. *Corresponding author, https://www.nature.com/articles/s41531-022-00324-9, Impact Factor: 9.3

  2. 2. Kumar, G.*, Dey, S.K.* and Kundu, S., 2021. Corrigendum to Herbs and their bioactive ingredients in cardio-protection: underlying molecular mechanisms and evidences from clinical studies. Phytomedicine, p.153753.*equal contribution. https://doi.org/10.1016/j.phymed.2021.153828, Impact Factor: 6.66

  3. 3. Kumar, G.*, Dey, S.K.* and Kundu, S., 2021. Herbs and their bioactive ingredients in cardio-protection: underlying molecular mechanisms and evidences from clinical studies. Phytomedicine, p.153753. *equal contribution. https://doi.org/10.1016/j.phymed.2021.153753, Impact Factor: 6.66

  4. 4. Dey SK, Saini M, Prabhakar P, and Kundu S. Dopamine ? hydroxylase as a potential drug target to combat hypertension. Expert Opinion on Investigational Drugs. 2020; 29(9):1043-1057. https://doi.org/10.1080/13543784.2020.1795830, Impact Factor: 6.5

  5. 5. Kumar G, Dey SK, and Kundu S. Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions. Life Sciences, Volume: 259, article number: 118377, DOI: https://doi.org/10.1016/j.lfs.2020.118377 (2020), Impact Factor: 6.78

  6. 6. Dey, JK, Mukherjee A, Dey SK, Pramanik A, Giri S, and Pratap M. "A systematic review on the efficacies and therapeutic interventions of homoeopathic medicines in combating viral disorders with implications in the currently undergoing homoeopathic treatment efforts of SARS-CoV-2 infection (COVID-19)."International Journal of High Dilution Research, 19 (3): 27-39 (2020). https://doi.org/10.1016/j.tox.2017.10.005, Impact Factor: 1

BOOK CHAPTERS

  1. 01. Diksha Rani, Smaranjot Kaur, Shahjahan, Joy Kumar Dey, Sanjay Kumar Dey. Engineering immune response to regulate cardiovascular disease and cancer. Advances in Protein Chemistry and Structural Biology. DOI: https://doi.org/10.1016/bs.apcsb.2023.12.004, Impact Factor: 5.4

  2. 02. Shahjahan, Dey JK, Dey SK. Translational bioinformatics approach to combat cardiovascular disease and cancers. Advances in Protein Chemistry and Structural Biology. 2024;139:221-261. https://doi.org/10.1016/bs.apcsb.2023.11.006. Impact Factor: 5.4

  3. 03. Shahjahan, Sanjay Kumar Dey, Chapter 9 - Role of miRNA in monkeypox viral diagnosis and therapeutic developments,Editor(s): Vijay Kumar Prajapati, Rupal Ojha,MicroRNA in Human Infectious Diseases, Academic Press, 2024, Pages 201-219, ISBN 9780323996617, https://doi.org/10.1016/B978-0-323-99661-7.00002-3.

  4. 04. Kumar, G*, Dey, S.K.*, and Kundu, S. (2023). Nitric Oxide and Cardiovascular Diseases: Cardioprotection, Complications and Therapeutics. In: Ray, A., Gulati, K. (eds) Nitric Oxide: From Research to Therapeutics. Advances in Biochemistry in Health and Disease, vol 22. Springer, Cham. *Equal contributions. https://doi.org/10.1007/978-3-031-24778-1_3

  5. 05. Dey JK, Ahmedi, S, Jain, N, Bano, S, Manzoor N, and Dey SK. Effect of the Changing Climate and Urban Ecology on Spreading of Infectious Diseases Including SARS-CoV-2. In: Bhadouria, R, Upadhyay, S, Tripathi, S and Singh, P (eds.) Urban Ecology and Global Climate Change. John Wiley & Sons Limited, located at The Atrium, Southern Gate, West Sussex PO19 8SQ, United Kingdom. (2022) ISBN: 9781119807186, https://doi.org/10.1002/9781119807216.ch12

  6. 06. Choudhury, SP, Arora, A, Jain, J. and Dey SK. Climate change, urbanization and their impact on increased occurrence of cardiometabolic syndrome. In: Bhadouria, R, Upadhyay, S, Tripathi, S and Singh, P (eds.) Urban Ecology and Global Climate Change. John Wiley & Sons Limited, located at The Atrium, Southern Gate, West Sussex PO19 8SQ, United Kingdom. (2022) ISBN: 9781119807186, https://doi.org/10.1002/9781119807216.ch2

  7. 07. Dey SK, Senapati S. (2021) Insulin and Insulin-Like Growth Factor-1 Associated Cancers. In: Kumar S., Gupta S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_3

  8. 08. Dey SK, Senapati S. (2021) In Vivo Models for Obesity and Obesity Related Carcinogenesis. In: Kumar S., Gupta S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_14

  9. 09. Kundu S, Saini M, Dey SK, Kundu S. Dopamine Beta Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases. In Frontiers in Protein Structure, Function, and Dynamics 2020 (pp. 339-357). Springer, Singapore. https://doi.org/10.1007/978-981-15-5530-5_14

  10. 10. Kumar G*, Dey SK*, and Kundu S. Nitric oxide and cardiovascular diseases: Cardio protection, Complications and Therapeutics. 2022. Springer Nature, Singapore (Accepted) (2022) *Equal contributions.