Faculty


Prof. Sunit K. Singh

Director

Molecular Virology
Email: sunitsingh2000@gmail.com

Glimpse of Education and Career History

Prof. Sunit Kumar Singh is currently working as a Director of Dr. B R Ambedkar Center for Biomedical Research (ACBR), University of Delhi, Delhi. Prof. Singh completed his PhD degree from the University of Wuerzburg, Wuerzburg, Germany in the area of Molecular Infection Biology and his postdoctoral trainings from Yale University, School of Medicine, New Havenand University of California Davis Medical Centre, Sacramento, California, USA. He is a Professor of Molecular Immunology & Virology at the Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi & currently on deputation at ACBR.Prof. Singh has been the Head of the Molecular Biology Unit and Professor Incharge of the Center for Experimental Medicine & Surgery, at Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi. Prof. Singh led a research group in the area of molecular virology as a faculty member at CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India. Prof. Singh has done seminal work in the area of molecular virology and published his research findings in international peer reviewed journals

In addition to his original research publications in prestigious peer reviewed journals, Prof. Singh has published many books in the area of virology such as: "Neuroviral Infections- Vol-I and Vol-II", "Viral Hemorrhagic Fevers", "Human Respiratory Viral Infections" by CRC Press/ Taylor & Francis group, USA, Neglected Tropical Diseases-South Asia", Defense Against Biological Attacks- Vol-I and Vol-II by Springer, USA; "Viral Infections and Global Change", "Human Emerging and Re-emerging Infectious Diseases- Vol-I and Vol-II" by Wiley Blackwell, USA and "Defense Against Biological Attacks- Vol-I and Vol-II by Springer-Nature". Prof. Singh has been associated with many prestigious international journals as Section Editor, Deputy Editor, Corresponding Editor and Editorial Board Member. Prof. Singh contributed immensely in understanding the molecular pathogenesis of different vector borne viruses.

Honors and Awards:

  1. 01. 2023-Elected Fellow of the National Academy of Medical Sciences, India (FAMS)

  2. 02. 2023-Professor CNR Rao Education Foundation Award

  3. 03. 2023- Elected Fellow of Royal Society of Biology (FRSB)

  4. 04. 2022- Elected Fellow of National Academy of Sciences India (FNASc)

  5. 05. 2022-Prof. Sohail Ahmad Award of Indian Academy of Biomedical Sciences

  6. 06. 2022- ICMR National Award for Immunology

  7. 07. 2021-Elected Fellow ofIndian Academy of Neurosciences (FIAN)

  8. 08. 2020- ICMR-Prof. B. K Aikat OrationAward for Tropical Diseases

  9. 09. 2019-NAVBD-Molecular Biology Award of National Academy of Vector Borne Diseases

  10. 10. 2018-ICMR National Award for Virology

  11. 11. 2017-ICMR Chaturvedi Ghanshyam Das Jaigopal Memorial Award for Immunology

  12. 12. 2017-Dr. B.C. Roy Award of Medical Council of India

  13. 13. 2016-Outstanding Alumnus Award by GB Pant Univ. of Agril. &Tech, Pantnagar

  14. 14. 2016-Nature Travel Grant Award to deliver invited lecture Gordon Research Conference

  15. 15. 2015-ICMR-Dr. J. B Srivastav Memorial Oration Award for Virology

  16. 16. 2014- Institute of Medical Sciences, BHU, Research Publication Award

  17. 17. 2011-FEBS Journal Top Cited Paper Award

Selected Recent Publications:

  1. 01. Apoorva, Atul Kumar, Singh SK (2024), Dengue Virus NS1 hits hard at the barrier integrity of human cerebral microvascular endothelial cells via cellular microRNA dysregulations, Tissue Barriers, DOI: 10.1080/21688370.2024.2424628

  2. 02. Ahmad, F, Keshri, V, Singh, SK (2024), ORF3a of SARS-CoV-2 modulates PI3K/AKT signaling in human lung epithelial cells via hsa-miR-155-5p, International Journal of Biological Macromolecules, 2024, https://doi.org/10.1016/j.ijbiomac.2024.131734

  3. 03. Pandey N, Singh SK (2023), MicroRNA-155 triggers a cellular antiviral immune response against Chandipura virus in human microglial cells, Microbes and Infection .2023 Jun 14;105173. doi: 10.1016/j.micinf.2023.105173.

  4. 04. Bharadwaj U,Singh SK (2023), Zika Virus NS1 suppresses VE-Cadherin via hsa-miR-29b-3p/DNMT3b/MMP-9 pathway in Human Brain Microvascular Endothelial Cells; Cellular Signalling, DOI: 10.1016/j.cellsig.2023.110659

  5. 05. Shukla A, Rastogi M,Singh SK (2021), Zika virus NS1 suppresses the innate immune responses via miR-146a in human microglial cells, International Journal of Biological Macromolecules Dec 15;193(Pt B):2290-2296. doi: 10.1016/j.ijbiomac.2021.11.061

  6. 06. Bharadwaj U, Singh SK (2021), Zika Virus NS1 Suppresses VE-Cadherin and Claudin-5 via hsa-miR-101-3p in Human Brain Microvascular Endothelial Cells, Molecular Neurobiology, https://doi.org/10.1007/s12035-021-02548-x

  7. 07. Pandey N, Rastogi M, Singh SK (2021),Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-?B in human microglial cells. J Biomed Sci. doi: 10.1186/s12929-021-00748-0.

  8. 08. Rastogi M, Pandey N, Shukla A, Singh SK (2020), SARS Coronavirus 2: from Genome to InfectomeRespiratory Research, 21:318. doi: 10.1186/s12931-020-01581-z

  9. 09. Rastogi M, Singh SK (2020), Japanese Encephalitis Virus exploits microRNA-155 to suppress the non-canonical NF-?B pathway in human microglial cells, BBA - Gene Regulatory Mechanisms, 1863, (11), 194639, https://doi.org/10.1016/j.bbagrm.2020.194639

  10. 10. Rastogi M, Singh SK (2020), Zika Virus NS1 affects the Junctional Integrity of Human Brain Microvascular Endothelial Cells, Biochimie, 176 (2020), 52-61, 10.1016/j.biochi.2020.06.011

  11. 11. Agrawal M, Pandey N, Rastogi M, Dogra S, Singh SK (2019), Chikungunya Virus modulates the miRNA expression patterns in Human Synovial Fibroblasts Journal of Medical Virology, 92(2):139-148. doi: 10.1002/jmv.25588

  12. 12. Rastogi M, Singh SK (2019), Modulation of type-I Interferon response by hsa-miR-374b-5p during Japanese Encephalitis Virus infection in human microglial cells Front. Cell. Infect. Microbiol.,2019, Aug 9;9:291, 1-11. doi: 10.3389/fcimb.2019.00291

  13. 13. Agrawal M, Rastogi M, Dogra S, Pandey N, Basu A, Singh SK (2019), Chandipura Virus changes cellular miRNome in human microglial cells Journal of Medical Virology, 2019 Apr 24. doi: 10.1002/jmv.25491.

  14. 14. Rastogi M, Srivastava N, Singh SK (2018), Exploitation of microRNAs by Japanese Encephalitis virus in human microglial cells, Journal of Medical Virology;Apr;90(4):648-654. doi: 10.1002/jmv.24995.

  15. 15. Sharma N, Kumawat KL, Rastogi M, Basu A, Singh SK (2016), Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5, Scientific Reports2016 Jun 10;6:27685. doi: 10.1038/srep27685

  16. 16. Sharma N, Verma R, Kumawat KL, Basu A, Singh SK (2015), miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells, Journal of Neuroinflammation, Feb 18;12:30. doi: 10.1186/s12974-015-0249-0

  17. 17. Jadhav V, Krause K-H, Singh SK (2014), HIV-1 Tat C modulates NOX2 and NOX4 expressions through miR-17 in Human Microglial Cells, Journal of Neurochemistry. Dec;131(6):803-15. doi: 10.1111/jnc.12933.

  18. 18. Selvamani SP, Mishra R, Singh SK (2014), Chikungunya virus exploits miR-146a to regulate NF-?Bpathway in human synovial fibroblasts, PLoS One. Aug 1; 9(8): e103624. doi: 10.1371/journal.pone.0103624.

  19. 19. Mishra R,Singh SK (2014), HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability, BMC Neuroscience 2014 Jun 26; 15(1):80. doi: 10.1186/1471-2202-15-80).

  20. 20. Manocha GD, Mishra R, Sharma N, Kumawat KL, Basu A, Singh SK(2014), Regulatory role of TRIM21 in type-I interferon pathway in Japanese encephalitis virus infected human microglial cells Journal of Neuroinflammation, Feb 1;11:24. doi: 10.1186/1742-2094-11-24

  21. 21. Mishra R, Singh SK (2013), HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-Cadherin in Human Brain Microvascular Endothelial Cells, The Journal of Neuroscience 33(14):5992-6000; doi:10.1523/JNEUROSCI.4796-12.2013.

  22. 22. Mishra R, Chhatbar C, Singh SK(2012), HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia, Journal of Neuroinflammation, Jun 18;9:131. doi: 10.1186/1742-2094-9-131